Evidence map›Paper›PMID 40190723›Full record

ArticleAlgorithms2025

Finding Multiple Optimal Solutions to an Integer Linear Program by Random Perturbations of Its Objective Function.

Noah Schulhof, Pattara Sukprasert, Eytan Ruppin, Samir Khuller, Alejandro A Schäffer

Abstract read
In one paragraph

Article in Algorithms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Noah SchulhofCancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0003-9792-5869
Pattara SukprasertDatabricks Inc., San Francisco, CA 94105, USA.ORCID 0000-0003-4624-7546
Eytan RuppinCancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-7862-3940
Samir KhullerDepartment of Computer Science, Northwestern University, Evanston, IL 60201, USA.ORCID 0000-0002-5408-8023
Alejandro A SchäfferCancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-2147-8033

Funding

Discovery of genetic interactions in cancerZIABC011802 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI RUPPIN, EYTAN · 2018 to 2025
$19.6M
Intramural NIH HHS ZIA BC011802
6 · The paper itself

Abstract

Integer linear programs (ILPs) and mixed integer programs (MIPs) often have multiple distinct optimal solutions, yet the widely used Gurobi optimization solver returns certain solutions at disproportionately high frequencies. This behavior is disadvantageous, as, in fields such as biomedicine, the identification and analysis of distinct optima yields valuable domain-specific insights that inform future research directions. In the present work, we introduce MORSE (Multiple Optima via Random Sampling and careful choice of the parameter Epsilon), a randomized, parallelizable algorithm to efficiently generate multiple optima for ILPs. MORSE maps multiplicative perturbations to the coefficients in an instance's objective function, generating a modified instance that retains an optimum of the original problem. We formalize and prove the above claim in some practical conditions. Furthermore, we prove that for 0/1 selection problems, MORSE finds each distinct optimum with equal probability. We evaluate MORSE using two measures; the number of distinct optima found in

Indexed as

integer linear programmultiple optimaparallel algorithmsrandomized algorithmsselection problems

Identifiers

PMID40190723
PMCPMC11970949

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.