ArticleRSC advances2025
Microfluidic synthesis of stable and uniform curcumin-loaded solid lipid nanoparticles with high encapsulation efficiency.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- Curcumin Loaded ZIF 8 Nanomaterials Ameliorate Porcine Endometritis Like Lesions in a Mouse Model via Regulating Macrophage Polarization and Antibacterial Activity.Animals : an open access journal from MDPI · 2026Article
- Development of Curcumin-Loaded Hybrid Lipid-Polymeric Nanoparticles for Hypoxia-Related Applications.International journal of nanomedicine · 2026Article
- Advanced microfluidic techniques for the preparation of solid lipid nanoparticles: Innovations and biomedical applications.International journal of pharmaceutics: X · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Solid Lipid Nanoparticles (SLNs) are a suitable method for encapsulating poorly soluble curcumin by dispersing the drug in solid lipids. However, the commonly used bulk method has disadvantages such as low reproducibility and encapsulation efficiency. To overcome these issues, we used a microfluidic machine to achieve more uniform mixing, resulting in an encapsulation efficiency of over 60%. The synthesized SLNs released over approximately six days and demonstrated colloidal stability for two weeks without aggregation. To synthesize the SLNs, we equipped the microfluidic machine with a temperature controller, which enabled the large-scale production of more reproducible and stable SLNs compared to those synthesized using the existing microfluidic machines.
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Registered trials
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