Evidence map›Paper›PMID 40190622›Full record

ReviewJournal of toxicologic pathology2025

Comparative anatomy of respiratory bronchioles and lobular structures in mammals.

Yumi Umeda, Takeshi Izawa, Kei Kazama, Sachiko Arai, Junichi Kamiie, Shinichiro Nakamura, Kazuki Hano, Masaki Takasu, Akihiro Hirata, Susanne Rittinghausen and 1 more

Abstract readReview
In one paragraph

Review in Journal of toxicologic pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yumi UmedaNational Institute of Occupational Safety and Health, Japan, Organization of Occupational Health and Safety, 2-26-1 Muraoka-higashi, Fujisawa, Kanagawa 251-0015, Japan.
Takeshi IzawaLaboratory of Veterinary Pathology, Osaka Metropolitan University Graduate School of Veterinary Science, 1-58 Rinku-Orai-Kita, Izumisano, Osaka 598-8531, Japan.
Kei KazamaDepartment of Veterinary Medicine, Azabu University, School of Veterinary Medicine, 17-71 Fuchinobe 1-chome, Chuo-ku, Sagamihara 252-5201, Japan.
Sachiko AraiDepartment of Veterinary Medicine, Azabu University, School of Veterinary Medicine, 17-71 Fuchinobe 1-chome, Chuo-ku, Sagamihara 252-5201, Japan.
Junichi KamiieLaboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
Shinichiro NakamuraLaboratory of Laboratory Animal Science, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
Kazuki HanoGifu University Institute for Advanced Study, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Masaki TakasuGifu University Institute for Advanced Study, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Akihiro HirataCenter for One Medicine Innovative Translational Research (COMIT), Gifu University, 1-1 Yanagido, Gifu, 501-1193, Gifu, 501-1193, Japan.
Susanne RittinghausenFraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Nikolai-Fuchs-Strasse 1, 30625, Hannover, Germany.
Shotaro YamanoNational Institute of Occupational Safety and Health, Japan, Organization of Occupational Health and Safety, 2-26-1 Muraoka-higashi, Fujisawa, Kanagawa 251-0015, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rodents are widely used to study the toxicity of chemicals; however, differences between species indicate that the results from rodents are not always directly transferable to humans. The health of workers exposed to various chemicals and particulates at high doses or for long periods is at risk. Respiratory bronchioles and lobular structures, which are demarcated by interlobular septa, are key sites for occupational lung diseases such as pneumoconiosis; however, these structures vary among animal species. Understanding these differences is crucial for studying the pathology of human occupational lung diseases. However, there is a lack of reviews focusing on these structures in different species. This review explores the lung anatomy of various mammals and its functional importance in disease to connect animal studies with human occupational lung diseases. Our results indicate that artiodactyls, especially small pig breeds and goats, are ideal for research because their respiratory bronchioles and lobular structures are similar to those of humans. This review aims to enhance the use of experimental animal data and improve our understanding of human occupational lung diseases, thereby facilitating early disease detection, treatment, and prevention.

Indexed as

comparative anatomyinterlobular septumlobular structurelungrespiratory bronchiole

Identifiers

PMID40190622
PMCPMC11966126

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.