Effective treatment of refractory, locally metastatic squamous cell carcinoma of the leg with isolated limb perfusion: a case report with unexpected long progression-free interval.

Danai-Dionysia Kanatoula, Sebastian A Wohlfeil, Jens Jakob, Peter Hohenberger, Jochen Utikal

Abstract readCase Reports

In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Danai-Dionysia KanatoulaDepartment of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.

Sebastian A WohlfeilDepartment of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.

Jens JakobDivision of Surgical Oncology, Department of Surgery, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany.

Peter HohenbergerDivision of Surgical Oncology, Department of Surgery, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany.

Jochen UtikalDepartment of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-melanoma skin cancer (NMSC) is one of the most commonly diagnosed human malignancies and its incidence is steadily increasing. Locally advanced cutaneous squamous cell carcinoma of the extremities that is refractory to standard therapies can be challenging to treat, with amputation of the limb being the ultima ratio treatment. Here we present a 67-year-old female patient with metastatic SCC of the leg refractory to standard therapies who was effectively treated with isolated limb perfusion and is free of any sign of relapse since more than 3 years. This case report provides a brief review of the recent literature on isolated limb perfusion and how this effective treatment can preserve the patient's quality of life by avoiding radical surgery and its negative consequences through limb salvage.

Indexed as

isolated limb perfusionrhTNFαSCCsquamous cell carcinomatreatment

Identifiers

PMID40190565

DOI10.3389/fonc.2025.1549683

PMCPMC11968665

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.