Evidence map›Paper›PMID 40190535›Full record

ArticleAfrican health sciences2024

A case of toxoplasmic encephalitis in a patient on cancer chemotherapy in Uganda.

Yekosani Mitala, Raymond Atwine, Abraham Birungi, Ambaru Jacinta, Kuraishi Baluku, Semei Sekitene, Edwin Nuwagira

Abstract readCase Reports
In one paragraph

Article in African health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yekosani MitalaDepartment of Pathology, Mbarara University of Science and Technology, Mbarara city, Uganda.
Raymond AtwineDepartment of Pathology, Mbarara University of Science and Technology, Mbarara city, Uganda.
Abraham BirungiDepartment of Pathology, Mbarara University of Science and Technology, Mbarara city, Uganda.
Ambaru JacintaUganda Cancer Institute-Mbarara Satellite site, Mbarara city, Uganda.
Kuraishi BalukuUganda Cancer Institute-Mbarara Satellite site, Mbarara city, Uganda.
Semei SekiteneUganda Cancer Institute-Mbarara Satellite site, Mbarara city, Uganda.
Edwin NuwagiraDepartment of Medicine, Mbarara University of Science and Technology, Mbarara city, Uganda.

Funding

Improving Diagnostic Strategies for Post-Tuberculosis Lung Disease in Ugandan Primary Healthcare SettingsK43TW012781 · FIC · MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY · PI Edwin Nuwagira · 2024 to 2026
$327k
FIC NIH HHS K43 TW012781
6 · The paper itself

Abstract

Background: Reactivation of central nervous system (CNS) toxoplasmosis can be caused by immunosuppression (ISS) of any kind. However, anti-cancer chemotherapy combined with human immunodeficiency virus (HIV) induced ISS results in an atypical presentation that is fatal. Case presentation: A 46 years old man with a well-controlled infection of the human immunodeficiency virus presented with generalized tonic-clonic seizures following the second dose of anti-cancer chemotherapy for esophageal cancer. His brain's computerized tomography (CT) scan showed enlarged ventricles with no space-occupying lesions. Cerebrospinal fluid (CSF) smears stained with hematoxylin and eosin (H&E) revealed numerous bradyzoites and tachyzoites consistent with central nervous system toxoplasmosis. Conclusion: With a double burden of cancer and Human immunodeficiency virus (HIV) infection in low-income countries, this case raises awareness about the atypical presentation of CNS toxoplasmosis reactivation among patients on cancer chemotherapy.

Indexed as

Antineoplastic AgentsHIV InfectionsToxoplasmosis, CerebralHumansMaleMiddle AgedTomography, X-Ray ComputedToxoplasmaUgandaAntineoplastic Agentscase reportsub-Saharan AfricaToxoplasmosisUganda

Identifiers

PMID40190535
PMCPMC11970142

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.