Evidence map›Paper›PMID 40190516›Full record

Observational studyAfrican health sciences2024

Role of HE4 in evaluation of adnexal masses and its comparison with CA125, ROMA and RMI in premenopausal women.

Mini Sharma, Neeraj Kumar, Subhas Saha, Vanita Suri, G R Prasad, Radhika Srinivasan, Arnab Pal

Abstract readObservational StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in African health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mini SharmaPost Graduate Institute of Medical Education and Research, OBG.
Neeraj KumarDr Rajendra Prasad Government Medical College.
Subhas SahaPost Graduate Institute of Medical Education and Research, OBG.
Vanita SuriPost Graduate Institute of Medical Education and Research, OBG.
G R PrasadPost Graduate Institute of Medical Education and Research, OBG.
Radhika SrinivasanPostgraduate Institute of Medical Education and Research, Chandigarh, Cytology and Gynecological Pathology.
Arnab PalPost Graduate Institute of Medical Education and Research, Biochemistry.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ovarian cancer is the seventh most common cancer in women and is ranked third among gynaecological malignancies after cervical and uterine cancers. Prospective studies have failed to establish a definite screening programme based on tumour markers or ultrasonography. Objective: To evaluate potential role of Human Epididymis protein 4 (HE4) as a biomarker for diagnosis of various ovarian malignancies in premenopausal age group, either alone or as a part of diagnostic algorithm like Risk of Malignancy Algorithm (ROMA) and to analyse if it has any advantage over Cancer Antigen 125 (CA125) or Risk of Malignancy Index (RMI). Methods: It was an observational cross-sectional study which included 100 premenopausal women having ovarian mass and underwent surgery. The diagnostic performances of CA125, HE4, ROMA score and RMI for ovarian cancer were evaluated. Results: Postoperative histopathology confirmed 30% (n=30) women to have malignant ovarian tumors. According to receiver operating characteristic (ROC) analysis; area under curve (AUC) was maximum for ROMA (0.791) followed by HE4 (0.784), RMI (0.750) and CA125 (0.715). Conclusion: HE4 is not superior to CA125 but, it can be used in series or as part of diagnostic algorithm (ROMA) along with CA125 to get higher diagnostic accuracy for premenopausal women.

Indexed as

Biomarkers, TumorCA-125 AntigenOvarian NeoplasmsProteinsWAP Four-Disulfide Core Domain Protein 2AdultAlgorithmsCross-Sectional StudiesFemaleHumansMiddle AgedPremenopauseROC CurveBiomarkers, TumorCA-125 AntigenProteinsWAP Four-Disulfide Core Domain Protein 2WFDC2 protein, humanAdnexal massCA125HE4Ovarian neoplasmsRisk of malignancy algorithm (ROMA)Risk of malignancy index (RMI)

Identifiers

PMID40190516
PMCPMC11970180

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.