Evidence map›Paper›PMID 40190473›Full record

ArticleClinical, cosmetic and investigational dermatology2025

Cross-Reactivity: a Case of Paracetamol-Induced Generalized Bullous Fixed Drug Eruption Followed by Dipyrone-Induced Fixed Drug Eruption.

Yuanyuan Wang, Huan Xue, Hejun Dai, Lianjuan Yang

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In one paragraph

Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Yuanyuan Wang *Department of Medical Mycology, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Huan Xue *Department of Dermatologic Surgery, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Hejun DaiDepartment of Medical Mycology, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Lianjuan YangDepartment of Medical Mycology, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A fixed drug eruption (FDE) is a recurring adverse drug reaction that manifests as lesions on the same cutaneous or mucosal sites after exposure to the causative drug. It is characterized by erythematous or violaceous, round-to-oval patches with a dusky center. With each recurrence, the number and size of lesions can increase, raising the risk for generalized bullous fixed drug eruption (GBFDE). GBFDE, a rare and severe variant, presents with widespread bullae accompanied by characteristic FDE lesions. Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the primary causes of FDE. Although cross-reactivity between different groups of NSAIDs has been rarely reported in FDE cases, in this report we present a case of paracetamol-induced GBFDE followed by FDE triggered by cross-reactivity with dipyrone (metamizole).

Indexed as

cross-reactivitydipyronegeneralized bullous fixed drug eruptionparacetamolrecurrence

Identifiers

PMID40190473
PMCPMC11972605

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