ArticleInternational journal of reproductive biomedicine2025
Therapeutic potential of fennel essential oil and manganese in modulating steroidal hormonal imbalance and ovarian alterations in rats with polycystic ovarian syndrome: An experimental study.
Article in International journal of reproductive biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Review
- Integrative Approaches to Ovulation Induction in Polycystic Ovary Syndrome: A Narrative Review of Conventional and Complementary Therapies.Biomedicines · 2025Review
- The HER2 target for designing novel multi-peptide vaccine against breast cancer using immunoinformatics and molecular dynamic simulation.Biochemistry and biophysics reports · 2025Article
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Authors and funding
5 authors.
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Abstract
Background: Polycystic ovarian syndrome (PCOS) is a prevalent hormonal disorder among women of reproductive age, resulting in female infertility. Researchers are exploring safe and affordable treatments for this disorder. Objective: This study explored the therapeutic effects of fennel essential oil (FEO) and manganese (Mn) on hormonal and histological markers in rats with estradiol valerate-induced PCOS. Materials and Methods: In this experimental study, 35 adult female Wistar rats (9 wk old, 200-250 gr) were divided into 7 groups. For 14 days, groups 1-4 received normal saline intraperitoneally, sesame oil intramuscularly, FEO intraperitoneally, and Mn orally, respectively. PCOS was induced in remaining groups through a single intramuscular injection of estradiol valerate. 60 days after induction, the 6 Results: FEO significantly increased estrogen and progesterone levels in PCOS rats compared to the PCOS group (p Conclusion: FEO and Mn demonstrated potential in restoring hormonal balance and improving ovarian histology, offering promise as low-cost treatments for PCOS.
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