ArticleInternational journal of reproductive biomedicine2025
The restorative effect of platelet-rich plasma on estrous cycle disruption induced by arcuate nucleus lesion in female Wistar rats: An experimental study.
Article in International journal of reproductive biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors.
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Abstract
Background: Successful reproduction relies on a functioning hypothalamic-pituitary-gonad axis. Damage to this axis disrupts the estrus cycle and reproductive capability. Objective: This study aimed to evaluate the effects of single or multiple platelet-rich plasma (PRP) injections on repairing the damaged hypothalamic arcuate nucleus (ARC) and restoring the estrus cycle in Wistar rats. Materials and Methods: 90 female Wistar rats (2-3 months old, 250-280 gr) with regular estrous cycles were divided into a control group and 8 experimental groups (n = 10/each). After bilateral stereotaxic chemical surgery of the ARC using quinolinic acid (500 nmol/2 Results: Vaginal smear cytology indicated that PRP administration gradually restored the estrous cycle. Compared to the ARC Conclusion: These findings not only emphasized the importance of the ARC for the regularity of estrous cycle but also showed the potential effects of local PRP treatment in contribution to the protection/reconstruction of ARC.
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