Evidence map›Paper›PMID 40190378›Full record

ArticleNeuro-ophthalmology (Aeolus Press)2025

Neuro-Ophthalmic Characteristics of Patients with Tuberous Sclerosis Complex at a Tertiary Care Referral Centre.

Barbara D Smith, Lyba A Naseer, Aaron E Rice, John J Bissler, Asim F Choudhri, Lauren C Ditta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-ophthalmology (Aeolus Press), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Tuberous sclerosis complex.Nature reviews. Disease primers · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Barbara D SmithDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Lyba A NaseerDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Aaron E RiceDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
John J BisslerDepartment of Pediatrics, University of Tennessee Health Science Center and Le Bonheur Children's Hospital, Memphis, TN, USA.
Asim F ChoudhriDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Lauren C DittaDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberous Sclerosis Complex (TSC) is a multisystem neurocutaneous disorder with multiple neuro-ophthalmologic manifestations. The ophthalmologist plays an important role in the multi-disciplinary care team and should be familiar with this condition and its neuro-ophthalmic associations. A retrospective review of patients with TSC presenting to a neuro-ophthalmology clinic between 2015 and 2023 was performed. Patients had a diagnosis of TSC based on genetic testing or clinically definite disease (CDD) and at least one ophthalmic exam. We identified 135 patients. The mean age at the first exam was 14.1 ± 13.0 years. Seventy-three patients (54%) had retinal astrocytic hamartoma (RAH), bilateral in 33 (46%). Patients with TSC2 mutations and CDD were more likely to have RAHs than patients with TSC1 (

Indexed as

hamartomaophthalmologyoptical coherence tomographysubependymal giant cell astrocytomaTuberous sclerosis complex

Identifiers

PMID40190378
PMCPMC11970761

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.