ArticleHead & neck2025
HPV-Positive Squamous Cell Carcinoma Metastasis Without Clinical Evidence of Primary: The Posterior Oropharyngeal Wall May Be an Overlooked Location.
Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- HPV-Positive Squamous Cell Carcinoma Metastasis Without Clinical Evidence of Primary: The Posterior Oropharyngeal Wall May Be an Overlooked Location.Head & neck · 2025Article
- Survival and Prognostic Factors in Unresectable Head and Neck Cancer Patients.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundOropharyngeal squamous cell carcinoma (SCC) can present as cancer of unknown primary, where only cervical lymph node metastases are identified. Most tumors, particularly human-papillomavirus-associated ones, are located in the palatine/lingual tonsils. When this is not the case, additional imaging with 2-deoxy-2-[
methodsA 68-year-old male with bilateral cervical metastasis from an HPV-positive SCC, no primary tumor was identified despite thorough examination. [
resultsFrozen sectioning of the posterior tumor revealed SCC. Final histology confirmed the posterior wall tumor as the primary cancer.
conclusionsThe posterior oropharynx wall must be carefully investigated during the diagnostic workup for SCC of an unknown primary tumor as it can be the site of the primary tumor. Identification of the primary tumor reduces the need for further diagnostic surgery.
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