ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Photo-Biomodulation of the Hippocampus Using Near-Infrared Laser to Enhance Cognitive Function in Mice.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07736092 (Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery: a Randomized, Double-blind, Pseudo-modulation-controlled Preliminary Clinical Trial
Who cites it
6 citing papers in PubMed.
- Retinocortical in-sensor neuromorphic vision platform for NIR-augmented artificial vision.Nature communications · 2026Article
- Perioperative neurocognitive disorders as a neuroimmune landscape disorder: microglial priming, state heterogeneity, and time-dependent neuroinflammation.Frontiers in immunology · 2026Review
- Microglial PGC-1α alleviates synaptic damage and cognitive impairments following anesthesia and surgery by suppressing excessive synaptic pruning in aged mice.International journal of biological sciences · 2026Article
- Gut Microbiota-Targeted Photobiomodulation Ameliorates Alzheimer's Pathology via the Gut-Brain Axis: Comparable Efficacy to Transcranial Irradiation.Microorganisms · 2025Article
- PBM alleviates depression and anxiety like behaviors in mice: insight from local field potential.Behavioral and brain functions : BBF · 2025Article
- Photo-Biomodulation of the Hippocampus Using Near-Infrared Laser to Enhance Cognitive Function in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Photo-biomodulation (PBM) with near-infrared (NIR) laser emerges as a promising noninvasive therapy for enhancing cognitive function. Here the effects of PBM, equipped with an 808 nm NIR laser, on cognitive function are investigated when used to irradiate hippocampi of mice. NIR irradiation once a day for 5 min per day for 5 consecutive days significantly improves the learning and memory performance of naïve mice assessed with the Barnes and Y maze tests. PBM also significantly attenuates cognitive dysfunction following anesthesia and surgery, and lipopolysaccharide challenge, respectively. Cognitive enhancements are associated with increased neuronal oscillations and enhanced theta-gamma coupling in the hippocampal dentate gyrus (DG) during cognitive processing. High neuronal activation in the DG is evidenced by increased c-Fos expression and calcium signal intensity. The improvements are also associated with high-density cells in the DG together with facilitating local energy deposition and neuronal activation. NIR-laser-activated axonogenesis and oxidative phosphorylation-related genes assessed with single-cell RNA sequencing were seen in the DG. These findings suggest that PBM very likely holds great potential as a noninvasive therapy for cognitive dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.