ArticleInternational journal of laboratory hematology2025
Automated Red and White Blood Cell Counting in Capillary Microsamples by Sysmex-XN Predilution Mode.
Article in International journal of laboratory hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Integrated ESR and PLT-H Measurement Using the BC-6800 Plus Hematology Analyzer: A Comprehensive Analytical Evaluation.Journal of clinical laboratory analysis · 2026Article
- Nano-Enabled Microfluidic Platforms for Functional Immunomonitoring in Pediatric Sepsis.International journal of nanomedicine · 2026Review
- Automated Red and White Blood Cell Counting in Capillary Microsamples by Sysmex-XN Predilution Mode.International journal of laboratory hematology · 2025Article
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5 authors.
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Abstract
objectivesNeonatal patients present a challenge to the clinical laboratory because of their low blood volume. The Sysmex XN-series features a predilution (PD) mode allowing hematologic measurements with only 20-50 μL of blood. We verified the PD mode for analysis of selected hematologic parameters in 50 μL microsamples.
methodsMicrosamples were prepared from adult EDTA blood. White blood cell count (leukocytes, neutrophils, and lymphocytes) and red blood cell parameters (erythrocytes, hemoglobin, hematocrit, mean cell volume, and reticulocytes) were evaluated. The imprecision of the PD mode was evaluated over 3 days, and the accuracy was assessed by method comparison with the standard whole blood mode. The effect of capillary sampling, microsample stability during storage, and pneumatic tube transportation was evaluated. Finally, the bias was reproduced in a small sample of pediatric patients.
resultsFor white blood cells, the bias was ≤ 5.4% (95% CI: 4.5-6.2) and imprecision was below 3.5% (except at the lowest levels). Capillary sampling had little effect on PD analytical performance (bias ≤ 0.7% and imprecision ≤ 4.7%) and white blood cell counts were stable for 7 h at room temperature and after pneumatic tube transportation. The red blood cell parameters generally exceeded the allowable bias and imprecision. The bias of the pediatric samples remained within the 95% PI for the method comparison studies.
conclusionThe PD mode has acceptable analytical performance and preanalytical stability for white blood cell counts but not for red blood cell parameters. It may offer a low-volume alternative for hematologic monitoring.
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