Evidence map›Paper›PMID 40189930›Full record

ArticleJournal of intellectual disability research : JIDR2025

Feasibility and Preliminary Efficacy of an Executive Function Intervention for Young Children With Down Syndrome.

Miranda E Pinks, Madison M Walsh, Sara Colaianni, Sara Onnivello, Chiara Marcolin, Sarah Looney, Elisa Rossi, Francesca Pulina, Mark A Prince, Nathaniel R Riggs and 5 more

Abstract read
In one paragraph

Article in Journal of intellectual disability research : JIDR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Miranda E PinksColorado State University, Fort Collins, Colorado, USA.ORCID 0000-0002-9433-6765
Madison M WalshColorado State University, Fort Collins, Colorado, USA.
Sara ColaianniUniversity of Padua, Padua, Italy.
Sara OnnivelloUniversity of Padua, Padua, Italy.
Chiara MarcolinUniversity of Padua, Padua, Italy.
Sarah LooneyColorado State University, Fort Collins, Colorado, USA.
Elisa RossiUniversity of Padua, Padua, Italy.
Francesca PulinaUniversity of Padua, Padua, Italy.
Mark A PrinceUniversity of Southern California, Los Angeles, California, USA.
Nathaniel R RiggsColorado State University, Fort Collins, Colorado, USA.ORCID 0000-0002-1105-6718
Susan HepburnColorado State University, Fort Collins, Colorado, USA.
Lisa A DaunhauerColorado State University, Fort Collins, Colorado, USA.
Van Deusen KaylynColorado State University, Fort Collins, Colorado, USA.ORCID 0009-0008-2166-6166
Silvia LanfranchiUniversity of Padua, Padua, Italy.ORCID 0000-0003-2470-6019
Deborah J FidlerColorado State University, Fort Collins, Colorado, USA.ORCID 0000-0001-6208-456X

Funding

Executive Function Intervention for Young Children with Down SyndromeR61HD115161 · NICHD · COLORADO STATE UNIVERSITY · PI FIDLER, DEBORAH J · 2024 to 2025
$1.4M
Eunice Kennedy Shriver National Institute of Child Health and Human Development 1R61HD115161-01Fondation Jérôme Lejeune 2061NICHD NIH HHS R61 HD115161
6 · The paper itself

Abstract

backgroundIndividuals with Down syndrome (DS) have an elevated likelihood of challenges with executive function (EF) throughout the lifespan, and syndrome-informed intervention approaches that strengthen these foundations during early childhood may be beneficial. This single group baseline versus postintervention pilot study presents findings from the implementation of a syndrome-informed, parent-mediated intervention designed to support the development of EF in preschool-aged children with DS (EXPO: Executive Function Play Opportunities).

methodParticipants were 34 children aged 3-7 years old with DS and their caregivers. The full sample participated in a novel 12-week parent-mediated intervention focused on building working memory, inhibitory control, cognitive flexibility and planning skills. Participants were evaluated at baseline and poststudy for feasibility outcomes and preliminary evidence of intervention efficacy.

resultsActivities were feasible for families to implement and appropriate for the developmental range of participants in the study. Preliminary evidence of efficacy was observed via laboratory-based EF outcome measures. Within-sample heterogeneity in response to intervention was also observed.

conclusionsEXPO is feasible for a larger trial in its current form. Additional intervention modifications may further increase the potential impact of EXPO by addressing heterogeneity in presentations among young children with DS.

Indexed as

Down SyndromeExecutive FunctionOutcome Assessment, Health CareChildChild, PreschoolFeasibility StudiesFemaleHumansMalePilot ProjectsDown syndromeexecutive functionparent‐mediated interventionpilot study

Identifiers

PMID40189930
PMCPMC12197839

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.