Evidence map›Paper›PMID 40189866›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2025

Hypertension Exacerbates Endothelial Dysfunction in Patients With Atrial Fibrillation.

Samuel Thomas, Fiona L Wilkinson, Amy R Bland, Gregory Y H Lip, James P Fisher, Rehan T Junejo

Abstract read
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Samuel ThomasDepartment of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK.
Fiona L WilkinsonDepartment of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK.ORCID 0000-0002-0358-3489
Amy R BlandSchool of Psychology, Faculty of Health and Education, Manchester Metropolitan University, Manchester, UK.ORCID 0000-0002-7170-1491
Gregory Y H LipLiverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK.ORCID 0000-0002-7566-1626
James P FisherFaculty of Medical and Health Sciences, Department of Physiology, University of Auckland, Auckland, New Zealand.ORCID 0000-0001-7851-9222
Rehan T JunejoDepartment of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK.ORCID 0000-0002-0670-8339

Funding

Bristol-Myers Squibb-Pfizer Alliance CV185-481Manchester Institute of Sport PhD studentship
6 · The paper itself

Abstract

Atrial fibrillation (AF) and hypertension (HT) often coincide and both are independently associated with endothelial dysfunction. We tested the hypothesis that brachial artery flow-mediated dilation (FMD), an indicator of endothelial health, will be poorer in AF patients with HT (AF + HT) than AF without concurrent HT. In a cross-sectional design study, AF (n = 29; mean 70 years; 9 females) and AF + HT (n = 33; 68 years (p = 0.302); 14 females) patients underwent Duplex-Doppler ultrasound imaging of brachial artery diameter and flow velocity during baseline (2 min), distal tourniquet cuff inflation (5 min), and following cuff deflation (3 min). The peak increase in artery diameter following cuff deflation was taken as FMD and analyzed as absolute, percentage change, FMD and shear-rate area-under-the-curve (SR

Indexed as

Atrial FibrillationBrachial ArteryEndothelium, VascularHypertensionAgedBlood Flow VelocityCross-Sectional StudiesFemaleHumansMaleMiddle AgedUltrasonography, Doppler, DuplexVasodilationatrial fibrillationflow‐mediated dilatationhypertensionshear stress

Identifiers

PMID40189866
PMCPMC11973128

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.