ArticleAnnals of Saudi medicine
Association between human herpesviruses and head and neck squamous cell carcinoma: a molecular perspective.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Oral Health-Head and Neck Cancers: Addressing Confounding Through Negative Control and Quantitative Bias Analyses.Community dentistry and oral epidemiology · 2026Article
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4 authors.
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Abstract
backgroundHead and neck cancer (HNC) is the seventh most common malignant tumor. Herpesviruses are a significant risk factor in the multifactorial pathogenesis of HNC.
objectivesThis study aimed to investigate the association between herpesviruses and the development of head and neck squamous cell carcinoma (HN-SCC).
designExperimental study.
settingA university hospital in Turkey. PATIENTS AND
methodsPathological archive tissue samples of 500 patients were included in the study. These samples were categorized into two groups: those diagnosed with HN-SCC (n=300, malignant group [MG]) and those diagnosed with benign head and neck lesions (n=200, benign group [BG]). The presence of herpesvirus in samples was detected using polymerase chain reaction.
main outcome measuresAssociation of herpesviruses in the development of head and neck cancer. SAMPLE SIZE: 500 patients.
resultsHHV-1, -2, -7, and -8 were not detected in any samples. In the malignant group (MG), EBV-DNA was detected in 1 patient (0.3%) and HHV-6 DNA in 2 patients (0.6%), while in the benign group (BG), VZV-DNA was detected in 1 patient (0.5%), EBV-DNA in 3 patients (1.5%), CMV-DNA in 5 patients (2.5%), and HHV-6 DNA in 3 patients (1.5%). While no significant difference was found between the groups for VZV, EBV, and HHV-6, a statistically significant difference was found in favor of the benign group for CMV.
conclusionAlthough herpesvirus seroprevalence is relatively high in the population, the lack of viral genome in tissue samples indicates that other factors might be prominent in developing HN-SCC. LIMITATION: The storage conditions of the sample used (paraffinized sample) may have negatively affected the detection frequency of HHVs.
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