Evidence map›Paper›PMID 40189810›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Exposure to neighborhood concentrated poverty is associated with faster decline in episodic memory among midlife women.

Jinshil Hyun, Mary Schiff, Charles B Hall, Bradley M Appelhans, Emma Barinas-Mitchell, Rebecca C Thurston, Carrie A Karvonen-Gutierrez, Monique M Hedderson, Imke Janssen, Carol A Derby

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The social environment and cognitive aging over the life course: laying out critical concepts and research gaps.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinshil HyunSaul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-1168-065X
Mary SchiffUPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Charles B HallSaul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Bradley M AppelhansDepartment of Family and Preventive Medicine, Rush University Medical Center, Chicago, Illinois, USA.
Emma Barinas-MitchellDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rebecca C ThurstonDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Carrie A Karvonen-GutierrezDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Monique M HeddersonDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Imke JanssenDepartment of Family and Preventive Medicine, Rush University Medical Center, Chicago, Illinois, USA.
Carol A DerbySaul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.

Funding

The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old AgeU19AG063720 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHERRI-ANN M BURNETT-BOWIE · 2020 to 2026
$61.3M
WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI KRAVITZ, HOWARD M · 1994 to 2019
$11.9M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1994 to 2019
$10.7M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DERBY, CAROL A. · 1994 to 2019
$9.2M
Cardiovascular Epidemiology Training ProgramT32HL083825 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AKIRA SEKIKAWA · 2008 to 2026
$6.1M
Neighborhood characteristics, GPS-based activity space, and cognitive healthR00AG080126 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Jinshil Hyun · 2025 to 2026
$493k
Alzheimer's Association 23AARF-1020416Cardiovascular Epidemiology Training Program Central LaboratoryCardiovascular Epidemiology Training Program Coordinating CenterCardiovascular Epidemiology Training Program NIH Program OfficeCardiovascular Epidemiology Training Program University of Pittsburgh Graduate School of Public HealthNational Institute of Nursing Research (NINR)National Institute on Aging (NIA) K99AG080126National Institutes of Health (NIH)NHLBI NIH HHS T32 HL083825NIA NIH HHS K99 AG080126NIA NIH HHS R00 AG080126NIA NIH HHS U01 AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01 AG012554NIA NIH HHS U19 AG063720NINR NIH HHS U01 NR004061Office of Research on Women's Health (ORWH) U01AG012495Office of Research on Women's Health (ORWH) U01AG012505Office of Research on Women's Health (ORWH) U01AG012531Office of Research on Women's Health (ORWH) U01AG012535Office of Research on Women's Health (ORWH) U01AG012539Office of Research on Women's Health (ORWH) U01AG012546Office of Research on Women's Health (ORWH) U01AG012553Office of Research on Women's Health (ORWH) U01AG012554Office of Research on Women's Health (ORWH) U01NR004061Office of Research on Women's Health (ORWH) U19AG063720Sylvia and Leonard Marx Foundationthe Czap Foundation
6 · The paper itself

Abstract

introductionNeighborhood-level socioeconomic status (nSES) is associated with risk for cognitive impairment, but prior studies assessed nSES within an individual's own residential area without considering the distribution of nSES among adjacent areas.

methodsUsing up to 14 years of data from the Study of Women's Health Across the Nation (N = 1391, mean age = 54), we examined whether geographic clustering of concentrated neighborhood poverty was associated with cognitive decline over midlife.

resultsGreater neighborhood concentrated poverty was associated with faster decline in episodic memory but not in processing speed or working memory. Living in high concentrated poverty areas was linked to a 7% episodic memory decline per decade (both immediate and delayed recall), with Black women experiencing the steepest decline at 10% per decade (delayed recall). DISCUSSION: Women living in concentrated poverty areas exhibited accelerated decline in episodic memory during midlife. Neighborhood concentrated poverty may impact risk for future cognitive impairment and ADRD. HIGHLIGHTS: Living in concentrated poverty areas predicted a more rapid episodic memory decline. This pattern was most pronounced among Black women. The cohort was a racially/ethnically diverse cohort of midlife women across the US. Neighborhood concentrated poverty may contribute to the risk of ADRD.

Indexed as

Cognitive DysfunctionMemory DisordersMemory, EpisodicNeighborhood CharacteristicsPovertyResidence CharacteristicsBlack or African AmericanFemaleHumansLongitudinal StudiesMiddle AgedNeuropsychological TestsSocial ClassUnited StatesWhitecognitive declinedelayed recallepisodic memoryhot spots analysisimmediate recalllongitudinal analysismidlifeneighborhood concentrated povertyracesocioeconomic

Identifiers

PMID40189810
PMCPMC11972984

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.