ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Structural changes in cerebral microvasculature induced by ferroptosis contribute to blood-brain barrier disruption in Alzheimer's disease: an autopsy study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Role of the WNT signalling pathway in physiological and pathological blood-brain barrier.Annals of medicine · 2026Review
- From Dysbiosis to Blood-Brain Barrier Disruption: The Metabolite-Mediated Gut-Brain Axis in Alzheimer's Disease.Molecular neurobiology · 2026Review
- Ginsenosides: potential therapeutic implications in neurodegenerative diseases by inhibiting ferroptosis.Molecular biology reports · 2026Review
- Lecanemab alters basement membrane collagen IV in viable microvessels isolated from brains with high Alzheimer's disease neuropathology.Journal of Alzheimer's disease : JAD · 2026Article
- Ferroptosis in diabetic retinopathy: cellular heterogeneity, progression, and therapeutic targets.Molecular biology reports · 2026Review
- Endothelial ferroptosis in blood-brain barrier dysfunction and neuroinflammation: mechanisms and immune-vascular crosstalk.Frontiers in immunology · 2026Review
- Metabolic cell death networks in Alzheimer's disease: mechanistic links and therapeutic perspectives of ferroptosis, cuproptosis, and disulfidptosis.Frontiers in cell and developmental biology · 2026Review
- Traditional Chinese Medicine and Ferroptosis in Alzheimer's Disease: A Potential Therapeutic Approach.Drug design, development and therapy · 2026Review
- Review
- Plin4 modulates lipid droplet accumulation and ferroptosis in neurons exposed to benzo[a]pyrene.Cell death discovery · 2025Article
- Structural changes in cerebral microvasculature induced by ferroptosis contribute to blood-brain barrier disruption in Alzheimer's disease: an autopsy study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Ferroptosis in neurodegenerative diseases: potential mechanisms of exercise intervention.Frontiers in cell and developmental biology · 2025Review
- Deep medullary vein abnormalities associated with cognitive function and Alzheimer's disease plasma biomarkers in dementia-free older adults: A population-based study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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9 authors.
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Abstract
introductionCerebrovascular lesions are associated with cognitive impairment. However, the impact of AD neuropathological changes (ADNC) on cerebral microvasculature is not completely understood.
methodsTwelve decedents with ADNC and 15 matched controls were selected from the Brain Bank. The changes in the median tunica and basement membrane-related extracellular matrix (ECM) contents of the microvasculature were quantified and compared. Additionally, we explored the related mechanisms of agrin in pericytes.
resultsVenular collagenosis was significantly more severe in AD patients (p < 0.001), and ECM remolding was significantly correlated with ADNC. In the AD group, blood-brain barrier (BBB) disruption and decreased pericytes were observed. Finally, we confirmed that agrin induced ferroptosis in pericytes and BBB disruption in vitro. DISCUSSION: Our data indicate that venular collagenosis and significant ECM remolding are important contributors to ADNC. The mechanism by which agrin's role in disrupting the BBB by inducing ferroptosis presents a potential new target. HIGHLIGHTS: Changes in the median tunica and basement membrane-related ECM contents of the microvasculature were quantified in human brains. Venular collagenosis was significantly more severe in AD patients. In the AD group, BBB disruption and ECM remodeling were important contributors to AD neuropathological changes. Agrin disrupted the BBB by inducing ferroptosis in pericytes, which presents a potential new target.
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