Evidence map›Paper›PMID 40189753›Full record

ArticleMagnetic resonance in medicine2025

Time-course manganese chloride biodistribution and manganese-induced MRI contrast in mouse organs.

Keyu Zhuang, Kyle D W Vollett, Minbo Hou, Yan Chang, Hai-Ling Margaret Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Keyu ZhuangInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0009-0003-6282-1357
Kyle D W VollettInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Minbo HouShanghai InnoStar Bio-tech Co., Ltd., Shanghai, China.
Yan ChangShanghai InnoStar Bio-tech Co., Ltd., Shanghai, China.
Hai-Ling Margaret ChengInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-0733-9512

Funding

Canada Foundation for Innovation 34038Canadian First Research Excellence Fund #MbDPEFR1-2021-04Dean's Spark ProfessorshipNatural Sciences and Engineering Research Council of Canada RGPIN-2019-06137New Frontiers in Research Fund #NFRFE-2020-00509
6 · The paper itself

Abstract

purposeTo optimize manganese-enhanced MRI (MEMRI) in mice by profiling the time-course biodistribution and associated T

methodsManganese (Mn) biodistribution and Mn-induced T

resultsAn injection dose of 0.2 mmol/kg produced significant T

conclusionThe subcutaneous injection route provided substantial T

Indexed as

ChloridesContrast MediaMagnetic Resonance ImagingManganese CompoundsAnimalsFemaleMetabolic Clearance RateMiceOrgan SpecificityTissue DistributionChloridesContrast Mediamanganese chlorideManganese Compoundsheartkidneyslivermanganese biodistributionskeletal muscletoxicity

Identifiers

PMID40189753
PMCPMC12202720

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.