Evidence map›Paper›PMID 40189677›Full record

ArticleJournal of physiology and biochemistry2025

The TWIK2-mtDNA-NLRP3 inflammasome signaling in hepatic macrophages facilitates exercise-induced attenuation of hepatic inflammation and insulin resistance in db/db mice.

Tan Zhang, Jingcheng Fan, Xin Wen, Xuemei Duan

Abstract read
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In one paragraph

Article in Journal of physiology and biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tan ZhangSchool of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, PR China. zhangtan@sus.edu.cn.
Jingcheng FanSchool of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, PR China.
Xin WenSchool of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, PR China.
Xuemei DuanSchool of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, PR China.

Funding

National Natural Science Foundation of China 32300960
6 · The paper itself

Abstract

Exercise has been proved to be effective in ameliorating diabetes but the underlying mechanisms remain obscure. It has been recently demonstrated that overactivation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome led to hepatic insulin resistance. Therefore, we aimed to explore the role and underlying mechanism of NLRP3 inflammasome in exercise-mediated hepatic insulin resistance. Wild type and db/db mice were sedentary or subjected to 8-week moderate intensity exercise, liver tissues and primary hepatic macrophages were isolated. Exercise mitigated hepatic steatosis and enhanced the hepatic insulin sensitivity of db/db mice. More importantly, exercise reduced the protein expression of two-pore domain weak inwardly rectifying K

Indexed as

DNA, MitochondrialInflammasomesInsulin ResistanceLiverMacrophagesNLR Family, Pyrin Domain-Containing 3 ProteinPhysical Conditioning, AnimalAnimalsMaleMiceMice, Inbred C57BLSignal TransductionDNA, MitochondrialInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseDiabetesExerciseHepatic insulin resistanceMitochondrial DNANLRP3 inflammasomeTWIK2

Identifiers

PMID40189677

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.