Evidence map›Paper›PMID 40189671›Full record

ArticleHeart and vessels2025

Relationship between exercise tolerance and autonomic nervous system modulation after catheter ablation for paroxysmal atrial fibrillation.

Natsumi Toyoda, Tomotaka Yoshiyama, Shiho Wakasa, Shun Hirayama, Kohei Fukuda, Tomoya Yanagishita, Atsushi Shibata, Daiju Fukuda

Abstract read
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In one paragraph

Article in Heart and vessels, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natsumi ToyodaDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1 - 4- 3 Asahimachi, Abeno-ku, Osaka, 545 - 8585, Japan.
Tomotaka YoshiyamaDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1 - 4- 3 Asahimachi, Abeno-ku, Osaka, 545 - 8585, Japan. tomotaka0324@gmail.com.ORCID http://orcid.org/0000-0002-8187-533X
Shiho WakasaDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1 - 4- 3 Asahimachi, Abeno-ku, Osaka, 545 - 8585, Japan.
Shun HirayamaDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1 - 4- 3 Asahimachi, Abeno-ku, Osaka, 545 - 8585, Japan.
Kohei FukudaDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1 - 4- 3 Asahimachi, Abeno-ku, Osaka, 545 - 8585, Japan.
Tomoya YanagishitaDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1 - 4- 3 Asahimachi, Abeno-ku, Osaka, 545 - 8585, Japan.
Atsushi ShibataDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1 - 4- 3 Asahimachi, Abeno-ku, Osaka, 545 - 8585, Japan.
Daiju FukudaDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1 - 4- 3 Asahimachi, Abeno-ku, Osaka, 545 - 8585, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autonomic nervous system (ANS) modulation increases the heart rate (HR) after catheter ablation (CA) for paroxysmal atrial fibrillation (PAF). However, its influence on exercise tolerance (ET) is poorly understood. This single-center retrospective cohort study enrolled patients who underwent CA for PAF. To analyze the effects of ANS modulation on ET, cardiopulmonary stress testing was performed before and 3 and 12 months after CA. The final analysis included 25 patients in the cryoballoon ablation (CBA) group and 24 in the radiofrequency CA (RFCA) group. HR increased at 3 and 12 months after CA compared with preoperative values (64.8 ± 8.6 vs. 77.7 ± 10.9, p < 0.001; 64.8 ± 8.6 vs. 74.8 ± 11.4, p < 0.001). ANS modulation was more frequent in the CBA group than in the RFCA group at 3 and 12 months after CA (64% vs. 21%, p < 0.01; 48% vs. 4%, p < 0.01). However, no significant difference in ET was observed before and after CA (anaerobic threshold 15.2 ± 2.8 vs. 15.7 ± 2.8, p = 0.46; 15.4 ± 3.0 vs. 16.3 ± 3.9, p = 0.38; peak VO2 23.5 ± 5.7 vs. 24.4 ± 5.2, p = 0.44; 23.0 ± 6.0 vs. 25.3 ± 7.7; p = 0.43) at both 3 and 12 months after CA. ANS modulation was more frequently observed in the CBA group than in the RFCA group. ET was not worsened by ANS modulation after CA.

Indexed as

Atrial FibrillationAutonomic Nervous SystemCatheter AblationExercise ToleranceHeart RateAgedExercise TestFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesTime FactorsTreatment OutcomeAutonomic nervous system modulationCardiopulmonary stress testingCryoballoon ablationParoxysmal atrial fibrillation

Identifiers

PMID40189671

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.