Evidence map›Paper›PMID 40189628›Full record

ArticleNPJ digital medicine2025

A scoping review of OMOP CDM adoption for cancer research using real world data.

Liwei Wang, Andrew Wen, Sunyang Fu, Xiaoyang Ruan, Ming Huang, Rui Li, Qiuhao Lu, Heather Lyu, Andrew E Williams, Hongfang Liu

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Liwei Wang *McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Andrew Wen *McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Sunyang FuMcWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Xiaoyang RuanMcWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Ming HuangMcWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Rui LiMcWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Qiuhao LuMcWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Heather LyuDepartment of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Andrew E WilliamsClinical and Translational Science Institute, Tufts Medical Center, Boston, MA, USA.
Hongfang LiuMcWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA. hongfang.liu@uth.tmc.edu.

Funding

Semi-structured Information Retrieval in Clinical Text for Cohort IdentificationR01LM011934 · NLM · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HERSH, WILLIAM R, LIU, HONGFANG · 2014 to 2025
$5.1M
Predictive modeling of Alzheimer's Disease Related Dementias (ADRD) in the elderly population empowered by knowledge-driven data miningR01HG012748 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HONGFANG LIU · 2023 to 2026
$3.1M
Facilitate Observational Studies of Alzheimer's Disease and Alzheimer's Disease-Related Dementias Using Ontology and Natural Language ProcessingRF1AG072799 · NIA · YALE UNIVERSITY · PI LIU, HONGFANG, TAO, CUI · 2021 to 2021
$2.4M
Facilitate Observational Studies of Alzheimer's Disease and Alzheimer's Disease-Related Dementias Using Ontology and Natural Language ProcessingR01AG072799 · NIA · YALE UNIVERSITY · PI HONGFANG LIU, Cui Tao · 2025 to 2026
$1.7M
Cancer Prevention and Research Institute of Texas RR230020National Institute of Aging grant RF1AG072799NHGRI NIH HHS R01 HG012748NHGRI NIH HHS R01HG12748NIA NIH HHS R01 AG072799NIA NIH HHS RF1 AG072799NLM NIH HHS R01 LM011934U.S. National Library of Medicine R01LM11934
6 · The paper itself

Abstract

The Observational Medical Outcomes Partnership (OMOP) common data model (CDM) supports large-scale research by enabling distributed network analyses. However, the breadth of its adoption in cancer research is not well understood. We conducted a scoping review to describe the adoption of the OMOP CDM in cancer research. A total of 49 unique articles were included in the review, with 30 on the data analysis theme, and 20 on the infrastructure theme. This review highlighted that while the OMOP CDM ecosystem has enabled successful data support for cancer research, particularly for collaborative studies, ongoing model development and iterative improvement remain needed to fulfill additional research data needs. Expanding disease sites, specifically for rare cancers, integrating more diverse types of data sources, improving data quality, adopting advanced analytics methodology, and increasing multisite evaluations serve as important opportunities to facilitate secondary usage of observational data in future cancer research.

Identifiers

PMID40189628
PMCPMC11973147

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.