Evidence map›Paper›PMID 40189570›Full record

Trial reportEuropean journal of medical research2025

Comparison of effect of remimazolam and propofol on respiration of patients under deep sedation for colonoscopy: a prospective multicenter randomized controlled trial.

Zhengjia Wang, Renshu Zhan, Liqun Mo, Jin Zhang, Jie Hu, Shoupeng Tan, Qiongzhen He, Ping Li, Wekong Sun, Xiaobin Wang and 4 more

Abstract readRandomized Controlled TrialMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhengjia Wang *Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 25 Taiping Street, Luzhou, 646000, China.
Renshu Zhan *Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 25 Taiping Street, Luzhou, 646000, China.
Liqun MoDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 25 Taiping Street, Luzhou, 646000, China.
Jin ZhangDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Jie HuDepartment of Anesthesiology, Xuyong County People's Hospital, Xuyong, China.
Shoupeng TanDepartment of Anesthesiology, The Second People's Hospital of Guangyuan, Guangyuan, China.
Qiongzhen HeDepartment of Anesthesiology, Guangyuan Mental Health Center, Guangyuan, China.
Ping LiDepartment of Anesthesiology, The People's Hospital of Yuechi, Yuechi, China.
Wekong SunDepartment of Anesthesiology, Cangxi People's Hospital, Cangxi, China.
Xiaobin WangDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 25 Taiping Street, Luzhou, 646000, China.
Jun JiangDepartment of General Surgery (Thyroid Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Li LiuDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 25 Taiping Street, Luzhou, 646000, China.
Yingying ZhangDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 25 Taiping Street, Luzhou, 646000, China.
Yiping BaiDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 25 Taiping Street, Luzhou, 646000, China. baiyiping0608@163.com.

Funding

Sichuan International Medical Exchange & Promotion Association HR21002Sichuan Science and Technology Program 2022YFS0627Sichuan Science and Technology Program 2022YFS0632
6 · The paper itself

Abstract

backgroundRemimazolam recently became available as a sedative. The comparison of the respiratory suppression effects of remimazolam and propofol under deep sedation for colonoscopy was not thoroughly unclear, particularly with regard to the novel metric of time to first airway intervention. The goal of this study was to systemically compare the respiration profiles of the patients sedated with remimazolam and propofol at the comparable sedation level in the patients undergoing colonoscopy.

methodsFour hundred-fifty outpatients were randomly assigned to remimazolam (Group Rem, n = 225) and propofol (Group Pro, n = 225). The target sedation level was the modified Observer's Assessment of Alertness/Sedation ≤ 2. The primary outcome was elapsed time from anesthesia induction to first airway intervention. Secondary outcomes included incidence and severity of hypoxia and apnea, minute ventilation (MV), tidal volume (TV), and respiratory rate (RR).

resultsThe elapsed time from induction to the first airway intervention was 11 ± 8 min in Group Rem (n = 208) vs. 5 ± 6 min in Group Pro (n = 208, P < 0.001). Patients in Group Rem required less frequent airway intervention and had a lower incidence of and shorter duration of apnea than patients in Group Pro (all P < 0.001). MV at 1 min, 2 min, 4 min post-induction, and at the end of the procedure were higher in Group Rem than those in Group Pro (P < 0.001).

conclusionsPatients sedated with remimazolam vs. propofol during colonoscopy maintain improved respiration and require less frequent airway intervention, and have lower incidence of adverse events. Clinical trial registration and registry URL ChiCTR2000034527, registered at www.chictr.org.cn.

Indexed as

BenzodiazepinesColonoscopyDeep SedationHypnotics and SedativesPropofolRespirationAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesBenzodiazepinesHypnotics and SedativesPropofolremimazolamAnesthesiaColonoscopyRemimazolamSedationVentilation

Identifiers

PMID40189570
PMCPMC11974117

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.