Evidence map›Paper›PMID 40189299›Full record

ReviewInternal medicine (Tokyo, Japan)2026

Recent Advances in Molecular Targeted Therapy for Inflammatory Bowel Disease.

Tadakazu Hisamatsu, Jun Miyoshi, Minoru Matsuura

Abstract readReview
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tadakazu HisamatsuDepartment of Gastroenterology and Hepatology, Kyorin University School of Medicine, Japan.
Jun MiyoshiDepartment of Gastroenterology and Hepatology, Kyorin University School of Medicine, Japan.
Minoru MatsuuraDepartment of Gastroenterology and Hepatology, Kyorin University School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progress in the development of molecular-targeted therapies in the field of inflammatory bowel disease has been remarkable. With the advent of molecular-targeted agents, treatment strategies have changed, and higher-level treatment goals have been set. In terms of the long-term prognosis of inflammatory bowel disease, there has been a clear decline in the rate of surgery since 2000 when anti-tumor necrosis factor antibody preparations were introduced. However, a large number of molecular-targeted agents with diverse modes of action have appeared, and their positioning has become complicated and often confusing for clinicians. Furthermore, these agents are expensive and therefore present economic challenges. The selection of therapeutic agents for inflammatory bowel disease based on the mode of action and prediction of treatment effects continues to be a major issue, and it is hoped that artificial intelligence and machine learning will help resolve these problems.

Indexed as

Inflammatory Bowel DiseasesMolecular Targeted TherapyArtificial IntelligenceHumansMachine LearningTumor Necrosis Factor-alphaTumor Necrosis Factor-alphaartificial intelligencedifficult to treatinflammatory bowel diseasesmachine learningmolecular targeted therapytreat to target

Identifiers

PMID40189299
PMCPMC12900592

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.