Evidence map›Paper›PMID 40189290›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Small Intestinal Bacterial Overgrowth in a Healthy Female Patient Caused by Long-term Oral Proton Pump Inhibitor Administration.

Koichi Soga, Sotaro Yamada, Yuto Suzuki, Yumi Kusano, Ikuhiro Kobori, Yasumi Katayama, Masaya Tamano

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Koichi SogaDepartment of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Japan.
Sotaro YamadaDepartment of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Japan.
Yuto SuzukiDepartment of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Japan.
Yumi KusanoDepartment of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Japan.
Ikuhiro KoboriDepartment of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Japan.
Yasumi KatayamaDepartment of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Japan.
Masaya TamanoDepartment of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small-intestinal bacterial overgrowth (SIBO) causes gastrointestinal symptoms. Proton pump inhibitors (PPIs) are commonly used for acid peptic diseases; however, their long-term use can alter the gut microbiota, resulting in adverse effects. We herein report the case of a 26-year-old Japanese woman with SIBO caused by prolonged PPI use. After switching to a H2 receptor antagonist, her symptoms and blood test results improved. This case highlights the need to understand the pathogenesis of SIBO and also the risks associated with prolonged PPI use.

Indexed as

Blind Loop SyndromeIntestine, SmallProton Pump InhibitorsAdministration, OralAdultFemaleHumansTime FactorsProton Pump Inhibitorschronic idiopathic intestinal pseudo-obstructionfunctional dyspepsiahistamine H2 receptor antagonistproton pump inhibitorreflux esophagitissmall intestinal bacterial overgrowth

Identifiers

PMID40189290
PMCPMC12549032

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.