ArticleJournal of cachexia, sarcopenia and muscle2025
Multitrajectories of Frailty and Depression With Cognitive Function: Findings From the Health and Retirement Longitudinal Study.
Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Joint trajectories of sleep deviation risk and frailty and their associations with cognitive decline in middle-aged and older adults: a population-based cohort study.BMC public health · 2026Article
- Trajectories of Frailty and Depression and Their Associations with the Risk of Gastrointestinal and Liver Disease: Findings from China Health and Retirement Longitudinal Study and Validation of Survey of Health, Aging and Retirement in Europe.Healthcare (Basel, Switzerland) · 2026Article
- Association of frailty trajectories with osteoporosis and hip fracture in an older female population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Associations of childhood economic and psychosocial conditions with later-life cognitive function: a longitudinal analysis of the China health and retirement longitudinal study (2011-2020).BMC public health · 2026Article
- Depressive symptoms and risk of incident activities of daily living disability among older adults with symptomatic arthritis.Frontiers in medicine · 2026Article
- Multidimensional Depressive Symptom Exposure and Incident Cognitive Decline: A Prospective Cohort Study.Depression and anxiety · 2026Article
- Predictive Value of the Triglyceride-Glucose-Frailty Index for Depression and Cognitive Function in Perimenopausal Women: Insights from CHARLS.International journal of women's health · 2026Article
- Frailty in older adults with chronic obstructive pulmonary disease: preliminary findings of prevalence and care priorities.BMC geriatrics · 2025Article
- The relationship between cognitive impairment and quality of life in rural older adults with chronic diseases-parallel mediating effects of depressive symptoms and frailty.BMC geriatrics · 2025Article
- Influencing factors of initiation and maintenance of multidomain interventions in patients with mild cognitive impairment: a qualitative study.Frontiers in neurology · 2025Article
- ADL and Cognitive Function in Chinese Elderly: Mediating Role of Social Participation and Moderating Role of Intergenerational Support.Journal of multidisciplinary healthcare · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundLittle is known about the joint associations between trajectories of frailty and depression with cognitive function. This study aims to explore the multitrajectories of frailty and depression and their joint impact on cognition.
methodsA total of 8600 participants from the Health and Retirement Study (HRS) (1996-2018) were analysed using a group-based trajectory model for 10-year multitrajectories. Participants were classified into five groups based on their trajectories. Multivariable linear mixed models and Cox proportional hazards models were utilized.
resultsCompared with Group 1 (stable robust and nondepressed), Groups 2 ('worsening prefrailty without depression,' β = -0.022 SD/year), 3 ('stable prefrailty with escalating depressive symptoms,' β = -0.016 SD/year), 4 ('increasing frailty alongside worsening depressive symptoms,' β = -0.034 SD/year) and 5 ('high and escalating frailty with persistent depression,' β = -0.055 SD/year) exhibited accelerated cognitive decline. Dementia risk was significantly higher in G2 (HR = 1.26, 95% CI: 1.08-1.48), G3 (HR = 1.54, 95% CI: 1.31-1.80), G4 (HR = 1.81, 95% CI: 1.54-2.14) and G5 (HR = 1.86, 95% CI: 1.48-2.33) compared with G1.
conclusionsWorsening frailty and depression accelerate cognitive decline and risk of dementia, underscoring the need to address both conditions to mitigate cognition.
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