Evidence map›Paper›PMID 40189100›Full record

ArticleMolecular metabolism2025

A key role for parabrachial nucleus CGRP neurons in FGF1-Induced anorexia.

Jarrad M Scarlett, Eunsang Hwang, Nicole E Richardson, Caeley L Bryan, Ingrid Redford, Emily Quah, Erik Tyr R Odderson, Pique P Choi, Matthew K Hwang, Bao Anh Phan and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jarrad M ScarlettUniversity of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, 98109, USA; Department of Pediatric Gastroenterology and Hepatology, Seattle Children's Hospital, Seattle, WA, 98145, USA.
Eunsang HwangCenter for Hypothalamic Research, Department of Internal Medicine, Peter O'Donnell Jr. Brain Institute, the University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
Nicole E RichardsonUniversity of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, 98109, USA.
Caeley L BryanUniversity of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, 98109, USA.
Ingrid RedfordUniversity of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, 98109, USA.
Emily QuahUniversity of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, 98109, USA.
Erik Tyr R OddersonUniversity of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, 98109, USA.
Pique P ChoiUniversity of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, 98109, USA.
Matthew K HwangUniversity of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, 98109, USA.
Bao Anh PhanUniversity of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, 98109, USA.
Kelly KadlecUniversity of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, 98109, USA.
Kimberly M AlongeUniversity of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, 98109, USA; Department of Medicinal Chemistry, University of Washington, Seattle, WA, 98115, USA.
Gregory J MortonUniversity of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, 98109, USA.
Kevin W WilliamsCenter for Hypothalamic Research, Department of Internal Medicine, Peter O'Donnell Jr. Brain Institute, the University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA. Electronic address: kevin.williams@utsouthwestern.edu.
Michael W SchwartzUniversity of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, 98109, USA.

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4M
Diabetes, Obesity and Metabolism Training ProgramT32DK007247 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON, KRISTINA Marie UTZSCHNEIDER · 1986 to 2026
$10.0M
Novel Brain Mechanisms Controlling Glucose HomeostasisR01DK083042 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2008 to 2025
$7.6M
Neuroendocrine Control of Glucose MetabolismR01DK089056 · NIDDK · UNIVERSITY OF WASHINGTON · PI MORTON, GREGORY J · 2011 to 2024
$5.6M
Thermoregulatory circuits that regulate feedingR01DK124238 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON, Tune Hannes Pers · 2020 to 2026
$3.9M
Maternal immune activation remodeling of offspring glycosaminoglycan sulfation patterns during neurodevelopmentDP2AI171150 · NIAID · UNIVERSITY OF WASHINGTON · PI Kimberly Michele Alonge · 2023 to 2026
$2.0M
NIAID NIH HHS DP2 AI171150NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK083042NIDDK NIH HHS R01 DK089056NIDDK NIH HHS R01 DK124238NIDDK NIH HHS T32 DK007247
6 · The paper itself

Abstract

In addition to sustained glucose lowering, centrally administered fibroblast growth factor 1 (FGF1) induces a potent but transient anorexia in animal models of type 2 diabetes. To investigate the mechanism(s) underlying this anorexic response, the current work focused on a specific neuronal subset located in the external lateral subdivision of the parabrachial nucleus marked by the expression of calcitonin gene-related peptide (elPBN

Indexed as

AnorexiaCalcitonin Gene-Related PeptideFibroblast Growth Factor 1NeuronsParabrachial NucleusAnimalsMaleMiceMice, Inbred C57BLMice, TransgenicCalcitonin Gene-Related PeptideFibroblast Growth Factor 1AGRPAnorexiaCGRPFGF1Parabrachial nucleus

Identifiers

PMID40189100
PMCPMC12142633

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.