Evidence map›Paper›PMID 40188945›Full record

ArticleThe Journal of biological chemistry2025

YTHDF2 suppresses the 2C-like state in mouse embryonic stem cells via the DUX-ZSCAN4 molecular circuit.

Xiang Wu, Wanting Cai, Junjie He, Shiyin Zhang, Shen Wang, Lingci Huang, Haotian Zhang, Xiaoyan Sun, Jun Zhou, Xiao-Min Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiang WuSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.
Wanting CaiSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.
Junjie HeSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.
Shiyin ZhangSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.
Shen WangSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.
Lingci HuangSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.
Haotian ZhangSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.
Xiaoyan SunSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.
Jun ZhouSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, China. Electronic address: jz572@cpu.edu.cn.
Xiao-Min LiuSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, China. Electronic address: liuxm642@cpu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mouse embryonic stem cells (ESCs) consist of a rare population of heterogeneous 2-cell-like cells (2CLCs). These cells transiently recapitulate the transcriptional and epigenetic features of the 2-cell embryos, serving as a unique model for studying totipotency acquisition and embryonic development. Accumulating evidence has demonstrated that transcription factors and epigenetic modifications exert crucial functions in the transition of ESCs to 2CLCs. However, the roles of RNA modification in the regulation of the 2C-like state remain elusive. Using a DUX-induced 2CLCs system, we examine N

Indexed as

Mouse Embryonic Stem CellsRNA-Binding ProteinsTranscription FactorsAdenosineAnimalsMiceAdenosineN-methyladenosineRNA-Binding ProteinsTranscription FactorsYTHDF2 protein, mouse2-cell likeembryonic stem cellm(6)A modificationRNA decayYTHDF2

Identifiers

PMID40188945
PMCPMC12147224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.