Evidence map›Paper›PMID 40188880›Full record

ArticleJournal of neuroscience methods2025

Multi-day recordings and adaptive stimulation protocols for in-home collection of deep brain stimulation intracranial recordings.

Jonathan P Platt, Erin M Radcliffe, Steven L Klimczak, Stephen V Gliske, Christopher K Kovach, Dulce Maroni, Aviva Abosch, John A Thompson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jonathan P PlattUniversity of Colorado Anschutz Medical Campus, Dept. of Neurosurgery, Aurora, CO, USA. Electronic address: Jonathan.p.platt@cuanschutz.edu.
Erin M RadcliffeUniversity of Colorado Anschutz Medical Campus, Dept. of Neurosurgery, Aurora, CO, USA; University of Colorado Anschutz Medical Campus, Dept. of Bioengineering, Aurora, CO, USA.
Steven L KlimczakShepherd Center Rehabilitation Hospital, Atlanta, GA, USA.
Stephen V GliskeUniversity of Nebraska Medical Campus, Dept. of Neurosurgery, Omaha, NE, USA.
Christopher K KovachUniversity of Nebraska Medical Campus, Dept. of Neurosurgery, Omaha, NE, USA.
Dulce MaroniUniversity of Nebraska Medical Campus, Dept. of Neurosurgery, Omaha, NE, USA.
Aviva AboschUniversity of Nebraska Medical Campus, Dept. of Neurosurgery, Omaha, NE, USA.
John A ThompsonUniversity of Colorado Anschutz Medical Campus, Dept. of Neurosurgery, Aurora, CO, USA; University of Colorado Anschutz Medical Campus, Dept. of Neurology, Aurora, CO, USA; University of Colorado Anschutz Medical Campus, Dept. of Psychiatry, Aurora, CO, USA.

Funding

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers In Sleep Dysregulation and RepairUH3NS113769 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ABOSCH, AVIVA, HALPERN, CASEY HARRISON · 2020 to 2025
$5.2M
NINDS NIH HHS UH3 NS113769
6 · The paper itself

Abstract

backgroundWhile open-loop deep brain stimulation (DBS) is an effective therapy for the motor symptoms of Parkinson's Disease (PD), recent work has explored whether closed-loop adaptive DBS (aDBS) may better address fluctuating symptoms through patient-specific and symptom-relevant neurophysiological biomarkers. To aid these investigations, we designed an interface for the research-enabled Summit Medtronic RC+S (RC+S) implanted neurostimulator (INS) to collect multi-day recordings along with the implementation of aDBS therapy. NEW

methodWe developed applications in MATLAB for investigating optimal brain recording locations, setting thresholds for real-time analysis, determining the INS's position along with in-home recordings of neural activity, and implementation of aDBS algorithms.

resultsIn a pilot study conducted in PD subjects (n = 5), we successfully determined optimal DBS lead contacts for detecting maximal beta (13-30 Hz) activity for streaming in-home neural activity with closed-loop adjustments to stimulation amplitude (n = 24-27 days). Using a Bluetooth connection method we developed, 95.2 % in-home data was collected. COMPARISON WITH EXISTING

methodsThe software and hardware applications described in this report provide MATLAB based tools to enable a distributed strategy for interfacing with the RC+S deployed at in-home settings for multi-hour recordings.

conclusionsOur interface provides investigators using the RC+S, in the context of aDBS, access to chronic recordings in real-time while providing adaptive stimulation based on continuous data analysis in MATLAB using a USB or Bluetooth connection. Advancing the efforts to characterize relevant biomarkers and develop therapeutic aDBS strategies for those treated with DBS, such as PD.

Indexed as

BrainDeep Brain StimulationParkinson DiseaseAgedAlgorithmsElectrodes, ImplantedFemaleHumansImplantable NeurostimulatorsMaleMiddle AgedPilot ProjectsAdaptive DBSDeep brain stimulationParkinson's diseaseSleep dysfunctionSubthalamic nucleus

Identifiers

PMID40188880
PMCPMC13453296

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.