ArticleGynecologic and obstetric investigation2025
Endometriosis, Raynaud's Syndrome, and Migraine: A Retrospective Study of 12 Million Women.
Article in Gynecologic and obstetric investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Endometriosis, Anxiety, Allergic Rhinoconjunctivitis, and Asthma: A Population-Based Study.Gynecologic and obstetric investigation · 2026Article
- Beyond pelvic pathology: retinal microvascular rarefaction as a systemic marker in endometriosis.BMC women's health · 2025Article
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6 authors.
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Abstract
<p>Objective: Our study focused on evaluating a possible relationship between endometriosis, Raynaud's syndrome, or migraine among women.
designThis was a cross-sectional population-based study. Participants/Materials; Setting; Methods: We used 12,684,067 hospitalized patient records in the Healthcare Cost and Utilization Project (HCUP) database between 2007 and 2014. We calculated the prevalence of endometriosis, Raynaud's syndrome, and migraine. We also evaluated the possible role of depression, anxiety, and autoimmune diseases to eliminate confounding factors. Unadjusted and adjusted multivariate logistic regressions were applied to evaluate the relationship between variables.
resultsUnadjusted analysis revealed a strong association between endometriosis and Raynaud's syndrome and migraine (OR = 2.491; 95% CI: 1.677-3.699). After adjusting for sociodemographic characteristics as well as depression and anxiety, the association remained significant (OR = 1.779; 95% CI: 1.166-2.716). Among younger patients aged 18-35 with endometriosis, the associations were stronger with Raynaud's syndrome (adjusted OR = 1.61, 95% CI = 1.20-2.16) and migraine (adjusted OR = 2.59, 95% CI = 2.47-2.72). LIMITATIONS: The HCUP database is cross-sectional in nature, and hence, we could not establish the temporal relationship between endometriosis, Raynaud's syndrome, and migraine. Also, the severity of endometriosis and the treatment received by the patients were not included in the dataset, and it prevented us from investigating the role of potential confounding factors.
conclusionOur study suggests an association between endometriosis, Raynaud's syndrome, and migraine. It is possible that these conditions share a similar mechanism possibly vascular reaction and endothelial dysfunction related to chronic inflammation. </p>.
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