Evidence map›Paper›PMID 40188346›Full record

ArticleArthritis research & therapy2025

Concomitant Sjögren's disease in patients with NMOSD: impacts on neurologic disease severity and recurrence.

Wanqing Wu, Wenbo Yang, Bo Deng, Helian Li, Xiaoni Liu, Hai Yu, Xiang Zhang, Minrui Liang, Xiangjun Chen

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Article in Arthritis research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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0cells of the map it votes in
5citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Wanqing WuDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, 200040, China.
Wenbo YangDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, 200040, China.
Bo DengDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, 200040, China.
Helian LiHuman Phenome Institute, Fudan University, Shanghai, 200438, China.
Xiaoni LiuDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, 200040, China.
Hai YuDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, 200040, China.
Xiang ZhangDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, 200040, China.
Minrui LiangDepartment of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China. mliang10@fudan.edu.cn.
Xiangjun ChenDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, 200040, China. xiangjchen@fudan.edu.cn.ORCID 0000-0002-8108-9013

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to characterize the phenotype of neuromyelitis optica spectrum disorder (NMOSD) in the presence and absence of Sjogren's disease (SjD) and to develop a predictive nomogram to evaluate the risk of coexisting SjD within a single tertiary-center cohort of NMOSD patients.

methodsParaclinical and clinical features of patients with SjD were compared between NMOSD patients with SjD and those without SjD. Zstats v1.0 was utilized to randomly allocate participants into a derivation group (108 patients) and a validation group (47 patients) at a ratio of 7:3. Logistic regression analysis was used to assess the effectiveness of our predictive model, and a nomogram was created to illustrate the findings.

resultsA total of 155 NMOSD patients who were serologically positive for AQP4-IgG were cross-sectionally recruited (70 NMOSD patients with SjD [45.16%] and 85 NMOSD patients without SjD [54.84%]). Independent predictors of coexisting SjD were age upon recruitment (P = 0.002); Expanded Disability Status Scale (EDSS) score (P = 0.023); blood white blood cell (WBC) count (P = 0.049); and rheumatoid factor (RF) (P = 0.049), anti-SSA (Ro), and anti-SSB (La) antibody positivity (P < 0.001; P = 0.012). The nomogram had an area under the receiver operating characteristic (ROC) curve (AUC) (95% confidence interval [CI]) of 0.95 (0.89, 1.00) in the derivation cohort and 0.91 (0.79, 1.00) in the validation cohort. Survival curve analysis revealed that the EDSS score in the NMOSD patients with SjD was associated with clinical relapse, and these patients reached an EDSS score of 4.0 earlier than those without SjD.

conclusionNMOSD patients with SjD manifested more severe disease at attack and relapsed earlier than those without SjD. The nomogram established by combining age upon recruitment; EDSS score; blood WBC count; and RF, anti-SSA (Ro), and anti-SSB (La) antibody levels can significantly predict the risk of NMOSD combined with SjD.

Indexed as

Neuromyelitis OpticaSjogren's SyndromeAdultAquaporin 4Cohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedNomogramsRecurrenceSeverity of Illness IndexAquaporin 4AQP4-IgGNeuromyelitis optica spectrum disorderNomogramPrognosisSjogren's disease

Identifiers

PMID40188346
PMCPMC11971889

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.