Evidence map›Paper›PMID 40188329›Full record

ArticleArchives of public health = Archives belges de sante publique2025

Prevalence, mutation distribution, and economic burden of thalassemia in China: a systematic review and regional analysis.

Aiqi Cai, Xiaohu Liu, Qingwen Ma, Guangyu He, Chanchan Jing, Jing He, Fanyi Zeng, Baosheng Zhu

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of public health = Archives belges de sante publique, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Aiqi Cai *Faculty of Life Science and Technology, Medical School, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
Xiaohu Liu *Department of Medical Genetics, Yunnan Provincial Key Laboratory for Birth Defects and Genetic Diseases, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, Yunnan Provincial Clinical Medical Center for Blood Diseases and Thrombosis Prevention and Treatment, the First People'S Hospital of Yunnan Province & Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, China.
Qingwen MaShanghai Children'S Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University School of Medicine, 24/1400 West Beijing Road, Shanghai, 200040, China.
Guangyu HeDepartment of Medical Genetics, Yunnan Provincial Key Laboratory for Birth Defects and Genetic Diseases, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, Yunnan Provincial Clinical Medical Center for Blood Diseases and Thrombosis Prevention and Treatment, the First People'S Hospital of Yunnan Province & Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, China.
Chanchan JingDepartment of Medical Genetics, Yunnan Provincial Key Laboratory for Birth Defects and Genetic Diseases, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, Yunnan Provincial Clinical Medical Center for Blood Diseases and Thrombosis Prevention and Treatment, the First People'S Hospital of Yunnan Province & Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, China.
Jing HeFaculty of Life Science and Technology, Medical School, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
Fanyi ZengShanghai Children'S Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University School of Medicine, 24/1400 West Beijing Road, Shanghai, 200040, China. fzeng@vip.163.com.
Baosheng ZhuFaculty of Life Science and Technology, Medical School, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China. bszhu@aliyun.com.

Funding

National Natural Science Foundation of China 81760037Yunling Scholar Project of Yunnan Province YNWR-YLXZ-2019-0005
6 · The paper itself

Abstract

backgroundThalassemia poses a significant public health and economic challenge in China. Comprehensive data on its epidemiology, mutation spectrum, and economic impact are critical for improving prevention and treatment.

methodsThis systematic review, adhering to PRISMA guidelines, analyzed studiesP{lea published between 1987 and 2024 from PubMed, FMRS, and CNKI. Data from 29 eligible studies, covering 679,697 individuals across 17 regions, were standardized using next-generation sequencing benchmarks.

resultsThe national carrier rate was 8.95%, with -

conclusionsWhile regional screening has reduced incidence since 1987, the disease continues to strain China's healthcare system. These findings highlight the pressing need to expand national prevention programs to mitigate its health and economic impacts. Insights from this review are vital for shaping public health strategies in high-prevalence areas.

Indexed as

ChinaDecreasingIncidencePreventionThalassemia

Identifiers

PMID40188329
PMCPMC11972477

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.