ArticleBMC nutrition2025
Dietary mineral patterns are associated with the pre-diabetes regression and progression: the Tehran lipid and glucose study (TLGS).
Article in BMC nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- TyG-BMI as a Marker of Metabolic Status and Its Association with Bone Quality and Mineral Metabolism: A Sex-Specific Analysis.Journal of clinical medicine · 2026Article
- Association between estimated pulse wave velocity and impaired fasting glucose: a multicenter retrospective cohort study in China.Frontiers in endocrinology · 2026Article
- Impact of zinc and chromium deficiency on gene expression in type 2 diabetes mellitus.Scientific reports · 2025Article
- Prediabetes in Transition: Insights from the Tehran Lipid and Glucose Study.International journal of endocrinology and metabolism · 2025Review
- Zinc and Adipose Organ Dysfunction: Molecular Insights into Obesity and Metabolic Disorders.Current nutrition reports · 2025Review
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Abstract
aimWe investigated the potential association between dietary mineral patterns and longitudinal change of glycemic status among individuals with prediabetes (Pre-DM).
methodsThis study included 1456 individuals with Pre-DM (mean age of 47.2 ± 12.8, and 52.5% men) who participated in the third (2006-2008) and fourth (2009-2011) examinations of the Tehran Lipid and Glucose Study (TLGS) that followed up until 2015-2017. The participants' habitual dietary intakes of minerals were assessed using a semi-quantitative food frequency questionnaire (FFQ) at baseline. Principle factor analysis (PCA) identified three major mineral patterns (with a total variance of 92.3%), including multi-mineral (MM) (characterized by higher loads of phosphorous, zinc, calcium, magnesium, and copper), chromium-selenium (Cr-Se), and iron-manganese (Fe-Mn) patterns. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of developing type 2 diabetes (T2D) and regression to normal glucose regulation (NGR) across tertile categories of mineral patterns score.
resultsAfter a median follow-up of 5.8 years, the incidence rates of T2D and NGR was 23.8% and 46.8%, respectively. After adjustment of T2D risk score (i.e., composed of age, sex, family history of diabetes, history of gestational diabetes, body mass index, and physical activity level) and dietary confounders, Cr-Se and Fe-Mn patterns were associated with an increased chance of returning to NGR by 26% (HR = 1.26, 95% CI = 1.02-1.55) and 42% (HR = 1.42, 95% CI = 1.14-1.76), respectively. Fe-Mn pattern was also associated with a reduced risk of developing T2D (HR = 0.67, 95% CI = 0.49-0.92).
conclusionOur findings emphasize the potential benefits of dietary Fe-Mn and Cr-Se intakes in pre-diabetic individuals.
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