Evidence map›Paper›PMID 40188312›Full record

ArticleMolecular psychiatry2025

The functional role of locus coeruleus microglia in the female stress response.

Cora E Smiley, Brittany S Pate, Samantha J Bouknight, Evelynn N Harrington, Aaron M Jasnow, Susan K Wood

Abstract read
In one paragraph

Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Sex-specific role of microglia in ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Cora E SmileyDepartment of Pharmacology, Physiology, and Neuroscience; University of South Carolina School of Medicine, Columbia, SC, 29209, US.
Brittany S PateDepartment of Pharmacology, Physiology, and Neuroscience; University of South Carolina School of Medicine, Columbia, SC, 29209, US.
Samantha J BouknightDepartment of Pharmacology, Physiology, and Neuroscience; University of South Carolina School of Medicine, Columbia, SC, 29209, US.
Evelynn N HarringtonDepartment of Pharmacology, Physiology, and Neuroscience; University of South Carolina School of Medicine, Columbia, SC, 29209, US.
Aaron M JasnowDepartment of Pharmacology, Physiology, and Neuroscience; University of South Carolina School of Medicine, Columbia, SC, 29209, US.ORCID 0000-0002-4015-4202
Susan K WoodDepartment of Pharmacology, Physiology, and Neuroscience; University of South Carolina School of Medicine, Columbia, SC, 29209, US. Susan.Wood@uscmed.sc.edu.ORCID 0000-0001-5732-3335

Funding

Estrogen-mediated mechanisms of stress susceptibilityR01MH113892 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI WOOD, SUSAN KATHLEEN · 2018 to 2022
$2.0M
Locus coeruleus-norepinephrine regulation of stress-induced anxiety and opioid reinstatementF32DA058380 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SMILEY, CORA · 2023 to 2024
$146k
BLRD VA I01 BX002664BLRD VA I01 BX005661NIDA NIH HHS F32 DA058380NIMH NIH HHS R01 MH113892U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01-MH113892U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) F32-DA058380
6 · The paper itself

Abstract

Neuropsychiatric disorders that result from stress exposure are highly associated with central inflammation. Our previous work established that females selectively exhibit heightened proinflammatory cytokine production within the noradrenergic locus coeruleus (LC) along with a hypervigilant behavioral phenotype in response to witnessing social stress. Notably, ablation of microglia using pharmacological techniques prevents this behavioral response. These studies were designed to further investigate the impact of stress-induced neuroimmune signaling on the long-term behavioral and neuronal consequences of social stress exposure in females using chemogenetics. We first characterized the use of an AAV-CD68-G

Indexed as

Locus CoeruleusMicrogliaStress, PsychologicalAnimalsClozapineFemaleNeuronsRatsRats, Sprague-DawleyClozapineclozapine N-oxide

Identifiers

PMID40188312
PMCPMC12339389

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.