Evidence map›Paper›PMID 40188311›Full record

ArticleMolecular psychiatry2025

Translational research approach to social orienting deficits in autism: the role of superior colliculus-ventral tegmental pathway.

Alessandro Contestabile, Nada Kojovic, Giulia Casarotto, Farnaz Delavari, Patric Hagmann, Marie Schaer, Camilla Bellone

Abstract read
In one paragraph

Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Superior Colliculus Projections Drive Dopamine Neuron Activity and Movement But Not Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alessandro Contestabile *Department of Basic Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0001-6528-1403
Nada Kojovic *Department of Psychiatry, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0003-0116-2485
Giulia CasarottoDepartment of Basic Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0009-0003-2176-7630
Farnaz DelavariDepartment of Psychiatry, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Patric HagmannDepartment of Radiology, University Hospital of Lausanne and University of Lausanne, Lausanne (CHUV-UNIL), Vaud, Switzerland.ORCID 0000-0002-2854-6561
Marie SchaerDepartment of Psychiatry, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland. marie.schaer@unige.ch.
Camilla BelloneDepartment of Basic Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland. camilla.bellone@unige.ch.ORCID 0000-0002-6774-6275

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 163859Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_212219
6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) is characterized by impairments in social interaction and repetitive behaviors. A key characteristic of ASD is a decreased interest in social interactions, which affects individuals' ability to engage with their social environment. This study explores the neurobiological basis of these social deficits, focusing on the pathway between the Superior Colliculus (SC) and the Ventral Tegmental Area (VTA). Adopting a translational approach, our research used Shank3 knockout mice (Shank3

Indexed as

Superior ColliculiVentral Tegmental AreaAnimalsAutism Spectrum DisorderAutistic DisorderChildChild, PreschoolDisease Models, AnimalFemaleHumansMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsMicrofilament ProteinsNerve Tissue ProteinsShank3 protein, mouse

Identifiers

PMID40188311
PMCPMC12240802

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.