ArticleInternational journal of obesity (2005)2025
IGFBP-1 and IGF-I in relation to adiposity and mortality from midlife to old age in the Swedish Adoption/Twin Study of Aging.
Article in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesInsulin-like growth factor-binding protein (IGFBP)-1 is a marker of insulin resistance. Lower IGFBP-1 is associated with increased adiposity. The aims of this study were to determine whether IGFBP-1 and its ligand, IGF-I, are associated with weight and waist measurements across mid-life to old age, and predict survival. SUBJECTS/
methodsThe Swedish Adoption/Twin Study of Aging (SATSA) includes extensive in-person testing of same-sex twins over a 30-year period. The dataset of twins for which baseline fasting IGFBP-1 (n = 512; 251 twin pairs) and IGF-I (n = 537; 262 twin pairs) measurements were available (from 1986) was stratified by birth cohort. Latent growth curve modeling was used to determine whether BMI and waist-to-height ratio (WHtR) and their change, differed as a function of IGFBP-1 or IGF-I. Survival data was collected by linkage to the Swedish Tax Agency.
resultsIGFBP-1 correlated inversely with insulin concentrations. There was a curvilinear relationship between BMI and age, increasing until 70-75 years and then declining, fitting a quadratic model. Lower IGFBP-1 was associated with higher BMI at the intercept, 73 years (1.8 kg/m
conclusionLower circulating IGFBP-1 concentrations are associated with increased adiposity but not change in adiposity, across the lifespan from middle to old age.
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