Evidence map›Paper›PMID 40188230›Full record

ArticleBone marrow transplantation2025

Protective factors, management and prognosis of mixed chimerism after allogeneic hematopoietic stem cell transplantation for severe aplastic anemia in children.

Jian Liu, Yumiao Mai, Zhaohe Jing, Linchao Zhao, Hongyun Niu, Simin Qiu, Pengpeng Dong

Abstract read
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In one paragraph

Article in Bone marrow transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jian Liu *Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. fccliuj@zzu.edu.cn.ORCID http://orcid.org/0000-0003-0850-0838
Yumiao Mai *Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zhaohe JingDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.ORCID http://orcid.org/0009-0003-6497-7611
Linchao ZhaoDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Hongyun NiuDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Simin QiuDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Pengpeng DongDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mixed chimerism (MC) frequently arises in children with severe aplastic anemia (SAA) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Nonetheless, there is a paucity of research regarding potential predictors and effective interventions. This retrospective study, performed on 150 pediatric patients with SAA who underwent allo-HSCT between December 2015 and June 2022, explored the characteristics, risk factors, treatment, and prognosis of MC. A total of 29 patients (19.3%) developed MC following allo-HSCT, with two individuals experiencing MC twice. The CTX + ATG regimen was associated with the development of MC. Peripheral blood (PB) + bone marrow (BM) stem cell graft and a high number of CD34

Indexed as

Anemia, AplasticHematopoietic Stem Cell TransplantationTransplantation ChimeraTransplantation ConditioningAdolescentChildChild, PreschoolFemaleHumansInfantMalePrognosisRetrospective StudiesTransplantation, Homologous

Identifiers

PMID40188230

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.