ArticlePediatric research2025
Everolimus and Sunitinib potentially work as therapeutic drugs for infantile hemangiomas.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Targeted Therapies in Infantile Hemangiomas and Vascular Malformations: From β-Blockers to PI3K/AKT/mTOR Inhibitors.Journal of cellular and molecular medicine · 2026Review
- Determinants of proliferation and involution in infantile hemangioma: macrophage crosstalk, endothelial plasticity, and metabolic rewiring.Frontiers in pediatrics · 2026Review
- Integrated proteomic analysis identifies TYMS-dependent AMPK-mTOR signaling in pancreatic neuroendocrine tumors.iScience · 2025Article
- Repurposing the Tyrosine Kinase Inhibitors Targeting FGFR and VEGFR Pathways for Cancer Therapy: A Comprehensive Review.Cancers · 2025Review
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Authors and funding
9 authors.
Funding
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Abstract
backgroundInfantile hemangiomas (IH) are common vascular tumors in infants, with no well-defined therapeutic agents currently available. Recent studies have explored molecular mechanisms involved in IH progression, but the lack of immortalized hemangioma-derived endothelial cell (iHemEC) models has limited drug discovery efforts.
methodsWe established an immortalized hemangioma-derived endothelial cell (iHemEC) expressing hemangioma markers and screened 18 potential drugs. Transcriptome profiling and Gene Set Enrichment Analysis (GSEA) were applied to assess the molecular effects of Everolimus and Sunitinib.
resultsSunitinib, Elimusertib, HIF-1 inhibitor-4, Rebastinib, and Everolimus inhibited iHemEC with lower IC
conclusionWe successfully developed an iHemEC model for in vitro drug screening and mechanistic study. Everolimus and Sunitinib emerged as promising therapeutic candidates for IH, providing a valuable basis for future research. CLINICAL PERSPECTIVES: Infantile hemangiomas (IH) are very common tumors in the neonatal period, with an incidence of approximately 2% to 10% among newborns, there are no well-defined therapeutic agents for IH, nor are there established human immortalized cell lines for in vitro studies. We establish an immortalized hemangioma-derived endothelial cell (iHemEC) which highly express markers of hemangioma. Drug screening was performed on iHemEC, Everolimus and Sunitinib were found efficiently induce cell death to iHemEC with much lower IC IMPACT: Developed a novel immortalized hemangioma-derived endothelial cell (iHemEC) model that replicates key IH features, overcoming limitations of primary cell models. Identified Sunitinib and Everolimus as promising therapeutic candidates with superior efficacy, supported by transcriptome and protein analyses. Revealed distinct drug mechanisms, with Everolimus targeting PI3K/AKT/mTOR and Sunitinib inducing chromosome instability and DNA damage.
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