ArticleInternational urology and nephrology2025
The relationship between serum salusins levels and atherosclerosis, endothelial dysfunction and cardiac morphology in autosomal dominant polycystic kidney disease.
Article in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeWe aimed to assess the associations between serum salusins levels and atherosclerosis, endothelial dysfunction and cardiac morphology in autosomal dominant polycystic kidney disease (ADPKD).
methodsThis study comprised 83 patients with ADPKD, and 53 healthy individuals. Salusin α and β levels were measured by ELISA. Echocardiography, flow-mediated vasodilatation, and carotid artery intima-media thickness measurements were conducted.
resultsSerum salusin α levels were significantly lower and the salusin β/α ratio was significantly higher in the patient group compared to Controls [2.64 (1.83-3.30) pg/mL vs. 3.20 (2.55-7.87) pg/mL, P = 0.002 and 2.81 (2.30-3.54) vs. 2.64 (2.02-3.18), P = 0.041, respectively]. Patients were further categorized into two groups: Group 1 (eGFR ≥ 60 mL/min/1.73 m
conclusionIn patients with ADPKD, salusin α was found to be significantly lower, while salusin β/α ratio was found to be significantly higher compared to healthy individuals. Low salusin α levels and high salusin β/α ratio were associated with LVM in advanced stages of ADPKD and salusin β was associated with proteinuria in early stage of ADPKD patients.
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