Evidence map›Paper›PMID 40188151›Full record

ArticleCell death discovery2025

Neuronal CDK5RAP3 deficiency leads to encephalo-dysplasia via upregulation of N-glycosylases and glycogen deposition.

Fanghui Chen, Minghui Xiang, Zhipeng Wang, Fan Yang, Junzhi Zhou, Zihan Deng, Susu Wang, Ping Li, Jieqi Tew, Wei Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. CDK5RAP3 Regulates Testosterone Production in Mouse Leydig Cells.International journal of molecular sciences · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Fanghui ChenCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Minghui XiangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Zhipeng WangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Fan YangDepartment of Human Anatomy, Bengbu Medical College, Bengbu, 233030, China.
Junzhi ZhouSchool of Basic Medicine, Guangdong Medical University, Dongguan, 523808, China.
Zihan DengCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Susu WangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Ping LiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Jieqi TewCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Wei ZhangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Honglin LiDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Yong TengDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, 30322, USA.ORCID http://orcid.org/0000-0002-1856-7289
Xiaobin ZhuDepartment of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, Wuhan City, 430071, China. xiaobinzhu@whu.edu.cn.
Yafei CaiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China. ycai@njau.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32270516
6 · The paper itself

Abstract

CDK5RAP3 is a binding protein of CDK5 activating proteins and also one of the key co-factors of the E3 enzyme in the UFMylation system. Several reports have implicated the involvement of CDK5 and other components of the UFMylation system in neuronal development and multiple psychiatric disorders. However, the precise role of CDK5RAP3 in neurons remains elusive. In this study, we generated CDK5RAP3 neuron-specific knockout mice (CDK5RAP

Identifiers

PMID40188151
PMCPMC11972371

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.