ArticleNature communications2025
Multi-proton dynamics near membrane-water interface.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hydrated proton complexes supplementation for tumor microenvironment reprogramming: a bioenergetic strategy targeting the Warburg effect and mitochondrial dysfunction.Frontiers in oncology · 2025Pooled it
- Proton wave propagation along collagen fibers.European biophysics journal : EBJ · 2026Article
- Glycolipids slow interfacial proton migration while preserving surface proton retention.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Quinones operate as proton-collecting antennas in energy-transducing membranes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Protonic Brain: Nanoscale pH Dynamics, Proton Wires, and Acid-Base Information Coding in Neural Tissue.International journal of molecular sciences · 2026Review
- Bee Venom Proteins Enhance Proton Absorption by Membranes Composed of Phospholipids of the Myelin Sheath and Endoplasmic Reticulum: Pharmacological Relevance.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Calculation of proton transmembrane-electrostatic interaction force and elucidation of the water droplet experiment with a transient protonic front.RSC advances · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Protons are crucial for biological energy transduction between membrane proteins. While experiments suggest rapid proton motion over large distances at the membrane-water interface, computational studies employing a single excess proton found the proton immobilized near the lipid headgroup. To address this discrepancy, we conduct DFTB3 simulations by incrementally adding protons up to three. We show that a single proton moves rapidly toward the nearest headgroup, where it is either repelled by a choline group or binds covalently to phosphatic oxygen. With multiple protons, while some are trapped by the lipid headgroups, the remaining proton diffuses laterally faster than in bulk water. Driven by excess energy, this proton initially jumps to the center of the water slab before relaxing into the third- and second-hydration shells. Lateral diffusion rates increase as the proton stabilizes in the second hydration shell. These results provide insights into proton dynamics near membranes and explain experimental observations.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.