Evidence map›Paper›PMID 40188123›Full record

ArticleAlzheimer's research & therapy2025

Insomnia, early and late rising are associated with small hippocampal volume and large white matter hyperintensity burden.

Clémence Cavaillès, Sylvaine Artero, Jerome J Maller, Isabelle Jaussent, Yves Dauvilliers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Sleep Abnormalities and Risk of Alzheimer's Disease.Current neurology and neuroscience reports · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Clémence CavaillèsInstitute for Neurosciences of Montpellier INM, University of Montpellier, INSERM, 80 Av. Augustin Fliche, Montpellier, 34295, France.
Sylvaine ArteroInstitute of Functional Genomics (IGF), University of Montpellier, CNRS, INSERM, Montpellier, France.
Jerome J MallerMonash Alfred Psychiatry Research Centre, Melbourne, VIC, Australia.
Isabelle JaussentInstitute for Neurosciences of Montpellier INM, University of Montpellier, INSERM, 80 Av. Augustin Fliche, Montpellier, 34295, France.
Yves DauvilliersInstitute for Neurosciences of Montpellier INM, University of Montpellier, INSERM, 80 Av. Augustin Fliche, Montpellier, 34295, France. y-dauvilliers@chu-montpellier.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSleep disturbances have been associated with an increased risk of dementia. The mechanisms remain unclear, although neurodegenerative and vascular pathways are potentially involved. Hence, our study aims to investigate the relationships between several clinical sleep and polysomnographic features and volumes of hippocampus (indicative of neurodegeneration) and white matter hyperintensities (WMH) (reflecting vascular processes).

methodsIn this cross-sectional study, 678 participants aged 65-80 from the French population-based ESPRIT cohort with MRI-measured hippocampus and/or WMH volumes were included. Self-reported sleep data were collected at baseline, and 176 participants underwent ambulatory polysomnography (PSG). We performed multivariable logistic regression to assess associations between sleep characteristics and hippocampal and WMH volumes.

resultsParticipants' median age was 70.7 years (Q1-Q3 = 67.8-74.0), with 52.4% being women. Early (≤ 6 am; odds ratio (OR) = 2.03, 95% confidence interval (CI) = 1.17;3.53) and late (> 8 am; OR = 2.14, 95%CI = 1.33;3.43) rising times were associated with low hippocampal volume. Early rising time (OR = 2.06, 95%CI = 1.24;3.43) and insomnia symptoms (OR = 1.84, 95%CI = 1.18;2.86 for 1 symptom, OR = 1.91, 95%CI = 1.18;3.09 for 2-3 symptoms) were associated with large WMH volume, whereas late bedtime (≥ 11 pm; OR = 0.56, 95%CI = 0.39;0.80) was associated with low WMH volume. Based on PSG data, higher rapid-eye movement (REM) sleep percentage (OR = 0.70, 95%CI = 0.50;0.96) was associated with low WMH volume, with similar trends for long sleep bouts duration, N3 and REM sleep durations (p = 0.05 to 0.07). Conversely, higher N2 sleep percentage (OR = 1.69, 95%CI = 1.09;2.62), longer NREM sleep bouts (OR = 1.46, 95%CI = 1.02;2.09), and higher periodic leg movements index (OR = 1.55, 95%CI = 1.02;2.26) were associated with large WMH volume. However, no PSG parameter associations remained after false discovery rate correction.

conclusionsDistinct associations between sleep characteristics and hippocampal and WMH volumes were observed, highlighting the important relationships between sleep, sleep timing and brain structure.

Indexed as

HippocampusSleep Initiation and Maintenance DisordersWhite MatterAgedAged, 80 and overCohort StudiesCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleOrgan SizePolysomnographyAgingHippocampusMRIPolysomnographySleep architectureSleep durationWhite matter hyperintensities

Identifiers

PMID40188123
PMCPMC11971846

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.