ArticleJournal of health, population, and nutrition2025
Association between vitamin A status, inflammations, and infections in children 36-59 months of age in rural Burkina Faso: A cross - sectional study.
Article in Journal of health, population, and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- A comparative study on indicators of vitamin A status and risk factors for sensitivity and specificity of the methods to detect vitamin A deficiency.Nutrition & metabolism · 2023Article
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9 authors.
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Abstract
backgroundAssessing vitamin A (VA) status using retinol and retinol-binding protein (RBP) in the presence of infection and inflammation remains challenging, as both markers prove to be unreliable during such physiological disturbances.
objectiveThis study aimed to assess the association between common infections and inflammation and VA status of children in rural Burkina Faso.
methodsTwo community-based cross-sectional studies were conducted in the villages of Sourkoudougou and Banakeledaga, in Southwestern Burkina Faso, one during the dry season (November 2016- January 2017) and the second during the rainy season (August- September 2017). In total, 115 children, 36-59 months of age, were included. The
resultsNo VA deficiency (TLR ≤ 0.1 µmol/g liver) was detected using RID method. Geometric means (95% confidence interval) of TBS and TLR were respectively 473 (412; 543) µmol and 0.86 (0.75; 0.99) µmol/g liver. One-third of study participants were found to have hypervitaminosis A (TLR > 1.0 µmol/g liver). Elevated CRP (> 5.0 mg/L) and AGP (> 1.0 g/L) were respectively detected in 1.9% and 28.6% of children. Positive malaria was diagnosed in 5 children. Intestinal parasites were found in one out of two (47.6%) participants, and other morbidities were detected in 2 participants. In a multivariable adjusted regression, significant positive weak associations were found between Log TLR and CRP concentrations (N = 79, β = 0.058, p = 0.004) and between Log TBS and CRP concentrations (N = 79, β = 0.054, p = 0.005).
conclusionStudy children were apparently healthy with high prevalence of asymptomatic intestinal parasites and chronic inflammation. TLR and TBS were positively associated with the acute phase protein CRP warranting further investigation.
trial registrationThe study was registered retrospectively (22 March 2018) as a clinical trial with the Pan African Clinical Trials Registry (Cochrane South Africa; PACTR201803002999356).
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