Evidence map›Paper›PMID 40188072›Full record

ArticleImmunity & ageing : I & A2025

Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination.

Paul Kunath, Dominik Pflumm, Bettina Moehrle, Vadim Sakk, Alina Seidel, Jan Münch, Hartmut Geiger, Reinhold Schirmbeck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity & ageing : I & A, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paul Kunath *Department of Internal Medicine I, University Hospital of Ulm, Ulm, Germany.
Dominik Pflumm *Department of Internal Medicine I, University Hospital of Ulm, Ulm, Germany.
Bettina MoehrleInstitute of Molecular Medicine, Ulm University, Ulm, Germany.
Vadim SakkInstitute of Molecular Medicine, Ulm University, Ulm, Germany.
Alina SeidelInstitute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Jan MünchInstitute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Hartmut GeigerInstitute of Molecular Medicine, Ulm University, Ulm, Germany.
Reinhold SchirmbeckDepartment of Internal Medicine I, University Hospital of Ulm, Ulm, Germany. reinhold.schirmbeck@uni-ulm.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAgeing-associated remodeling of the murine B cell system is accompanied with a reduction of CD19

resultsIn the same environment of young RAG1

conclusionsBoth DO-HSCs and DY-HSCs established in the young recipient BM to a similar extend, suggesting that the concomitant reduction in the de novo reconstitution of CD19

Indexed as

B cellsHematopoietic stem cellsIgG antibody responseOld immune systemSARS-CoV-2 spike vaccine

Identifiers

PMID40188072
PMCPMC11971919

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.