Evidence map›Paper›PMID 40188047›Full record

Trial reportBMC pregnancy and childbirth2025

Effects of M-DEPTH model of depression care on maternal depression, functioning, and HIV care adherence, and infant developmental over eighteen months post-partum: results from a cluster randomized controlled trial.

Glenn J Wagner, Bonnie Ghosh-Dastidar, Violet Gwokyalya, Laura J Faherty, Jolly Beyeza-Kashesya, Juliet Nakku, Linda Kisaakye Nabitaka, Dickens Akena, Janet Nakigudde, Victoria Ngo and 5 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03892915 (Depression Care to Improve Adherence to Prevention of Mother-to-Child-Transmission), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03892915 phase2 / phase3completednot on this map

Depression Care to Improve Adherence to Prevention of Mother-to-Child-Transmission (PMTCT) Care Continuum & Pregnancy Outcomes

TypeinterventionalSponsorRANDRan2019 to 2024Enrolled391ConditionsDepressionArmsevidence-based depression treatment
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Glenn J WagnerRAND Corporation, 1776 Main Street, Santa Monica, CA, 90407, USA. gwagner@rand.org.
Bonnie Ghosh-DastidarRAND Corporation, 1776 Main Street, Santa Monica, CA, 90407, USA.
Violet GwokyalyaSchool of Public Health, Makerere University, Kampala, Uganda.
Laura J FahertyRAND Corporation, 1776 Main Street, Santa Monica, CA, 90407, USA.
Jolly Beyeza-KashesyaMulago Specialized Women and Neonatal Hospital, Kampala, Uganda.
Juliet NakkuButabika National Referral Mental Hospital, Kampala, Uganda.
Linda Kisaakye NabitakaMinistry of Health, Kampala, Uganda.
Dickens AkenaCollege of Health Sciences, Makerere University, Kampala, Uganda.
Janet NakiguddeCollege of Health Sciences, Makerere University, Kampala, Uganda.
Victoria NgoRAND Corporation, 1776 Main Street, Santa Monica, CA, 90407, USA.
Ryan McBainRAND Corporation, 1776 Main Street, Santa Monica, CA, 90407, USA.
Hafsa LukwataMinistry of Health, Kampala, Uganda.
Leticia KyohangirweButabika National Referral Mental Hospital, Kampala, Uganda.
Barbara MukasaMildmay Uganda, Kampala, Uganda.
Rhoda K WanyenzeSchool of Public Health, Makerere University, Kampala, Uganda.

Funding

Depression Care to Improve Adherence to PMTCT Care Continuum & Pregnancy OutcomesR01MH115830 · NIMH · RAND CORPORATION · PI WAGNER, GLENN JOHN · 2018 to 2022
$3.1M
Integrating Counseling to Transform HIV Family Planning Services R01HD090981 · NICHD · RAND CORPORATION · PI GOGGIN, KATHY J, WAGNER, GLENN JOHN · 2016 to 2020
$2.6M
Child Mental Health in HIV-impacted Low-Resource Settings in Developing Countries: Global Research FellowshipD43TW011541 · FIC · WASHINGTON UNIVERSITY · PI MCKAY, MARY MCKERNAN, NAKASUJJA, NOELINE · 2020 to 2024
$1.7M
FIC NIH HHS D43 TW011541NICHD NIH HHS R01 HD090981NIMH NIH HHS R01MH115830
6 · The paper itself

Abstract

backgroundPerinatal depression is associated with poor outcomes related to HIV care adherence, maternal functioning, and early child development. We examined whether the M-DEPTH (Maternal Depression Treatment in HIV) depression care model-including antidepressant therapy and individual problem-solving therapy-and depression alleviation would affect improvement in each of these outcome domains.

methodsA sample of 354 pregnant women living with HIV (WLH) with at least mild depressive symptoms (177 in each of intervention and usual care control arms) enrolled in a cluster randomized controlled trial across eight antenatal care clinics in Uganda and had a live birth delivery. Longitudinal mixed effects models were used to examine survey data and chart-abstracted HIV viral load and antiretroviral pharmacy refill data collected at baseline and months 2, 6, 12 and 18 post-partum.

results69% had clinical depression at enrollment; 70% of women in the intervention group (including 96% of those with clinical depression) received depression treatment. Mixed-effects longitudinal regression analysis showed (1) strong effects of the intervention on maternal depression at each post-partum follow-up assessment; and (2) moderate effects of the intervention and reduced depression on maternal functioning (self-care and infant care, in particular). However, there was little evidence of effects of the intervention and depression reduction on early child development, maternal viral suppression, or ART adherence.

conclusionThese findings suggest that depression care for pregnant WLH is important for maternal mental health, but it also helps women to better manage parenting and care for their infant. Supplementary interventions may be needed to impact early child development.

trial registrationThe trial was registered with the NIH Clinical Trial Registry (clinicaltrials.gov: NCT03892915) on 27/03/2019.

Indexed as

Child DevelopmentDepressionDepression, PostpartumHIV InfectionsMedication AdherencePregnancy Complications, InfectiousAdultAntidepressive AgentsAnti-HIV AgentsFemaleHumansInfantInfant, NewbornLongitudinal StudiesPregnancyPrenatal CareAntidepressive AgentsAnti-HIV AgentsAntidepressant therapyChild developmentDepressionHIVMaternal functioningProblem solving therapy

Identifiers

PMID40188047
PMCPMC11971773

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.