Evidence map›Paper›PMID 40187771›Full record

ArticleRMD open2025

Venous vessel-wall assessment with superb microvascular imaging in Behçet syndrome.

Yasemin Kayadibi, Yesim Ozguler, Melike Melikoglu, Sinem Nihal Esatoglu, Ugur Kimyon, Ayse Kalyoncu Ucar, Ibrahim Adaletli, Gulen Hatemi

Abstract read
In one paragraph

Article in RMD open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Behçet's Syndrome.Current rheumatology reports · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yasemin Kayadibi *Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Radiology, Istanbul University-Cerrahpasa, Istanbul, Turkey.ORCID 0000-0003-1590-5382
Yesim Ozguler *Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey ozguler@iuc.edu.tr.ORCID 0000-0002-2082-4715
Melike MelikogluCerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.ORCID 0000-0003-0253-8368
Sinem Nihal EsatogluCerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.ORCID 0000-0001-5414-7305
Ugur KimyonCerrahpasa Faculty of Medicine, Department of Internal Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.ORCID 0000-0001-7283-0183
Ayse Kalyoncu UcarCerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Radiology, Istanbul University-Cerrahpasa, Istanbul, Turkey.ORCID 0000-0001-8433-1883
Ibrahim AdaletliCerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Radiology, Istanbul University-Cerrahpasa, Istanbul, Turkey.ORCID 0000-0003-4531-6466
Gulen HatemiCerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.ORCID 0000-0002-1952-1135

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSuperb microvascular imaging (SMI) provides a more sensitive assessment of small vessels compared with power and colour Doppler ultrasonography (PDUS and CDUS). We aimed to investigate the potential of SMI for use in research and clinical practice in Behçet syndrome (BS) and to gain a better understanding of erythema nodosum (EN) like and superficial thrombophlebitis (STM) lesions using SMI.

methodsWe studied 51 patients with BS and 31 patients with non-BS with red palpable lesions on physical examination. B-mode US, CDUS, PDUS and SMI were performed and recorded by the same radiologist and recorded images were additionally evaluated independently by another radiologist. Vessel-wall signal intensity of STM lesions by SMI was graded in four groups according to the percentages of the affected vessel-wall area (Grade 0: no signal, Grade 1: < 25%, Grade 2: 25%-50%, Grade 3: 50%-75% and Grade 4: >75%).

resultsThe lesions of 26 patients with BS and 17 patients with non-BS were diagnosed as STM with CDUS. SMI of STM lesions revealed vessel-wall signals in 21/26 patients with BS (81%), in contrast to only 3/17 (18%) patients with non-BS. While 16 of 21 patients with BS (76%) had at least grade 2 signal, only 1 of 3 non-BS had it. Lesions of 25 BS and 11 non-BS were diagnosed as EN by CDUS and SMI showed no vessel-wall signal in these patients.

conclusionsEvaluation of the vessel wall with SMI in BS may be a promising approach for showing inflammation as an inexpensive, non-invasive and reliable imaging method that does not require a contrast agent.

Indexed as

Behcet SyndromeMicrovesselsAdultErythema NodosumFemaleHumansMaleMiddle AgedThrombophlebitisUltrasonographyUltrasonography, Doppler, ColorYoung AdultBehcet SyndromeCardiovascular DiseasesSystemic vasculitisVasculitis

Identifiers

PMID40187771
PMCPMC11973801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.