Evidence map›Paper›PMID 40187744›Full record

Observational studyBMJ open respiratory research2025

Metabolic cost of physical rehabilitation in mechanically ventilated patients in critical care: an observational study.

Timothy O Jenkins, Dan Stieper Karbing, Stephen Edward Rees, Mathias Krogh Poulsen, Brijesh V Patel, Michael I Polkey, Vicky MacBean

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05101850 (Measurement of the Metabolic Cost of Inspiratory Muscle Training and Physical Rehabilitation in Mechanically Ventilated Patients; a Feasibility Study), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05101850 completednot on this map

Measurement of the Metabolic Cost of Inspiratory Muscle Training and Physical Rehabilitation in Mechanically Ventilated Patients; a Feasibility Study

TypeobservationalSponsorRoyal Brompton & Harefield NHS Foundation TrustRan2021 to 2022Enrolled40ConditionsMechanical Ventilation Complication
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Timothy O JenkinsRoyal Brompton and Harefield Hospitals, London, UK.ORCID http://orcid.org/0000-0002-8631-0725
Dan Stieper KarbingDepartment of Health Science and Technology, Aalborg Universitet, Aalborg, Denmark.
Stephen Edward ReesDepartment of Health Science and Technology, Aalborg Universitet, Aalborg, Denmark.
Mathias Krogh PoulsenIntramedic, Aalborg, Denmark.
Brijesh V PatelDivision of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London Division of Surgery Oncology Reproductive Biology and Anaesthetics, London, UK.
Michael I PolkeyDepartment of Respiratory Medicine, Royal Brompton Hospital and National Heart and Lung Institute, London, UK.
Vicky MacBeanCollege of Health, Medicine and Life Sciences, Brunel University of London, London, UK vicky.macbean@brunel.ac.uk.ORCID http://orcid.org/0000-0003-0268-2693

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysical rehabilitation is advocated to improve muscle strength and function after critical illness, yet interventional studies have reported inconsistent benefits. A greater insight into patients' physiological response to exercise may provide an option to prescribe individualised, targeted rehabilitation, yet there is limited data measuring oxygen consumption (VO

methodsWe conducted a prospective observational study on patients mechanically ventilated for ≥72 hours and able to participate in physical rehabilitation in critical care. Oxygen consumption was measured continuously using indirect calorimetry. A total of 29 measurements were taken from ten participants performing active sitting and standing exercise.

resultsMedian (IQR) first session baseline VO

conclusionsVO TRIAL REGISTRATION NUMBER: NCT05101850.

Indexed as

Critical CareCritical IllnessEnergy MetabolismExercise TherapyOxygen ConsumptionRespiration, ArtificialAgedCalorimetry, IndirectExerciseFeasibility StudiesFemaleHumansMaleMiddle AgedProspective StudiesCritical CareExercise

Identifiers

PMID40187744
PMCPMC11973748

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.