Evidence map›Paper›PMID 40187505›Full record

Trial reportThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2025

A randomized trial of open lung protective ventilation compared to conventional mechanical ventilation in deceased organ donors.

Lorraine B Ware, Tatsuki Koyama, Ciara M Shaver, Sharon Swain, John Nguyen, Ahmad Salehi, Gundeep Dhillon, Nancy Wickersham, Julia Maheshwari, Jonathan P Singer and 3 more

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03439995 (Goal of Open Lung Ventilation in Donors), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03439995 naterminatednot on this map

Goal of Open Lung Ventilation in Donors

TypeinterventionalSponsorVanderbilt University Medical CenterRan2018 to 2021Enrolled154ConditionsBrain Death, Organ Donation, Organ Transplant Failure or RejectionArmsOpen lung protective ventilation, Conventional ventilation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lorraine B WareDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: lorraine.ware@vumc.org.
Tatsuki KoyamaDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
Ciara M ShaverDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
Sharon SwainDonor Network West, San Ramon, California.
John NguyenDonor Network West, San Ramon, California.
Ahmad SalehiDonor Network West, San Ramon, California.
Gundeep DhillonDepartment of Medicine, Stanford University, Palo Alto, California.
Nancy WickershamDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Julia MaheshwariDepartment of Medicine, University of California, San Francisco, California.
Jonathan P SingerDepartment of Medicine, University of California, San Francisco, California.
S Samuel WeigtDepartment of Medicine, University of California, Los Angeles, California.
Jasleen KukrejaDepartment of Surgery, University of California, San Francisco, California.
Michael A MatthayDepartment of Medicine, University of California, San Francisco, California; Department of Anesthesia and the Cardiovascular Research Institute, University of California, San Francisco, California.

Funding

The GOLD Study: Goal of Open Lung Ventilation in DonorsR01HL126176 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARE, LORRAINE B · 2015 to 2020
$2.8M
NHLBI NIH HHS R01 HL126176
6 · The paper itself

Abstract

backgroundWe conducted a randomized trial of open lung protective ventilation (OLPV) compared to conventional ventilation (CV) in deceased donors. The primary outcome was lung utilization for transplantation.

methodsEligible donors were ≥13 years with PaO

resultsOne hundred and fifty three donors were randomized (74 to OLPV, 79 to CV) and included in the final analysis. Median duration of treatment was 50 hours and did not differ by arm. Donor lung utilization was 23% in the OLPV arm and 22% in the CV arm, p = 0.85. Change in PaO

conclusionsAn open lung protective ventilator strategy was safe but did not improve donor lung utilization or oxygenation compared to a conventional ventilator strategy in a population of US organ donors. NCT03439995.

Indexed as

Lung TransplantationRespiration, ArtificialTissue DonorsAdultFemaleHumansMaleMiddle AgedTidal VolumeTissue and Organ Procurementatelectasislung transplantationlung utilizationmechanical ventilationprimary graft dysfunction

Identifiers

PMID40187505
PMCPMC13213562

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.