Evidence map›Paper›PMID 40187356›Full record

ArticleCell reports. Medicine2025

MetaGP: A generative foundation model integrating electronic health records and multimodal imaging for addressing unmet clinical needs.

Fei Liu, Hongyu Zhou, Kai Wang, Yunfang Yu, Yuanxu Gao, Zhuo Sun, Sian Liu, Shanshan Sun, Zixing Zou, Zhuomin Li and 15 more

Abstract read
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Foundation Models Meet Medical Image Interpretation.Research (Washington, D.C.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Fei LiuInstitute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Macau, China; State Key Laboratory of Eye Health, Eye Hospital and Institute for Advanced Study on Eye Health and Diseases, Wenzhou Medical University, Wenzhou, China; National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau SAR 999078, China.
Hongyu ZhouInstitute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Macau, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Kai WangState Key Laboratory of Eye Health, Eye Hospital and Institute for Advanced Study on Eye Health and Diseases, Wenzhou Medical University, Wenzhou, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China; Department of Big Data and Biomedical AI, College of Future Technology, Peking University and Peking-Tsinghua Center for Life Sciences, Beijing, China.
Yunfang YuInstitute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Macau, China; Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Yuanxu GaoInstitute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Macau, China; State Key Laboratory of Eye Health, Eye Hospital and Institute for Advanced Study on Eye Health and Diseases, Wenzhou Medical University, Wenzhou, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China; Department of Big Data and Biomedical AI, College of Future Technology, Peking University and Peking-Tsinghua Center for Life Sciences, Beijing, China.
Zhuo SunState Key Laboratory of Eye Health, Eye Hospital and Institute for Advanced Study on Eye Health and Diseases, Wenzhou Medical University, Wenzhou, China; Department of Ophthalmology, The Third People's Hospital of Changzhou, Changzhou, China.
Sian LiuState Key Laboratory of Eye Health, Eye Hospital and Institute for Advanced Study on Eye Health and Diseases, Wenzhou Medical University, Wenzhou, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Shanshan SunState Key Laboratory of Eye Health, Eye Hospital and Institute for Advanced Study on Eye Health and Diseases, Wenzhou Medical University, Wenzhou, China; Department of Ophthalmology, The Third People's Hospital of Changzhou, Changzhou, China.
Zixing ZouInstitute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Macau, China; State Key Laboratory of Eye Health, Eye Hospital and Institute for Advanced Study on Eye Health and Diseases, Wenzhou Medical University, Wenzhou, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China; Guangzhou National Laboratory, Guangzhou, China.
Zhuomin LiState Key Laboratory of Eye Health, Eye Hospital and Institute for Advanced Study on Eye Health and Diseases, Wenzhou Medical University, Wenzhou, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Bingzhou LiState Key Laboratory of Eye Health, Eye Hospital and Institute for Advanced Study on Eye Health and Diseases, Wenzhou Medical University, Wenzhou, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Hanpei MiaoDongguan Hospital, Southern Medical University, Dongguan, China.
Yang LiuInstitute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Macau, China.
Taiwa HouConde S. Januário Hospital, Macau, China.
Manson FokInstitute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Macau, China.
Nivritti Gajanan PatilInstitute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Macau, China.
Kanmin XueNuffield Department of Neuroscience, Oxford University, Oxford, UK.
Ting LiInstitute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Macau, China; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau SAR 999078, China.
Eric OermannNYU Langone Medical Center, New York University, New York, NY, USA.
Yun YinFaculty of Health and Wellness, Faculty of Business, City University of Macau, Macau, China.
Lian DuanFaculty of Pediatrics and Department of Pediatric Surgery of the Seventh Medical Center, the Chinese PLA General Hospital, Beijing, China. Electronic address: duanlian301@163.com.
Jia QuNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China. Electronic address: jia.qu@163.com.
Xiaoying HuangDivision of Pulmonary Medicine, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou Key Laboratory of Interdisciplinary and Translational Medicine, Wenzhou Key Laboratory of Heart and Lung, Wenzhou, Zhejiang, China. Electronic address: huangxiaoying@wzhospital.cn.
Shengwei JinDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: jsw@wmu.edu.cn.
Kang ZhangInstitute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Macau, China; State Key Laboratory of Eye Health, Eye Hospital and Institute for Advanced Study on Eye Health and Diseases, Wenzhou Medical University, Wenzhou, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China; Guangzhou National Laboratory, Guangzhou, China. Electronic address: kang.zhang@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial intelligence makes strides in specialized diagnostics but faces challenges in complex clinical scenarios, such as rare disease diagnosis and emergency condition identification. To address these limitations, we develop Meta General Practitioner (MetaGP), a 32-billion-parameter generative foundation model trained on extensive datasets, including over 8 million electronic health records, biomedical literature, and medical textbooks. MetaGP demonstrates robust diagnostic capabilities, achieving accuracy comparable to experienced clinicians. In rare disease cases, it achieves an average diagnostic score of 1.57, surpassing GPT-4's 0.93. For emergency conditions, it improves diagnostic accuracy for junior and mid-level clinicians by 53% and 46%, respectively. MetaGP also excels in generating medical imaging reports, producing high-quality outputs for chest X-rays and computed tomography, often rated comparable to or superior to physician-authored reports. These findings highlight MetaGP's potential to transform clinical decision-making across diverse medical contexts.

Indexed as

Electronic Health RecordsMultimodal ImagingArtificial IntelligenceHumansTomography, X-Ray ComputedAI-assisted clinical decision supportgenerative foundation modelMetaGPmultimodal data analysis

Identifiers

PMID40187356
PMCPMC12047458

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.