Evidence map›Paper›PMID 40186840›Full record

ReviewClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2025

Oral microbes and gastrointestinal cancers: new strategies and insights.

Chenlu Huang, Yu Li, Cong He

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. From gut to mouth: salivary signatures of carcinogenic microbiota.Frontiers in cellular and infection microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chenlu HuangDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, 330006, Jiangxi Province, China.
Yu LiDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, 330006, Jiangxi Province, China.
Cong HeDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, 330006, Jiangxi Province, China. hecong.1987@163.com.ORCID http://orcid.org/0000-0002-1185-5456

Funding

National Natural Science Foundation of China no. 82260133
6 · The paper itself

Abstract

Gastrointestinal (GI) cancers are among the most prevalent cancers globally and represent a leading cause of cancer-related mortality. A distinctive characteristic of these cancers is their association with the microbes. Gut microbiota dysbiosis is widely recognized as a contributing factor in cancer development. Recent advancements in molecular techniques have increasingly underscored the role of oral microbes in GI cancers, especially colorectal cancer. Oral microbes, transported to the gut via swallowed saliva, have been shown to influence GI health. Both in vivo and in vitro investigations demonstrated the impacts of oral microbes in GI cancers. This review explores the changes in oral microbial diversity and relative abundance in esophageal, gastric and colorectal cancers as well as the underlying mechanisms. These mechanisms include immunomodulation, epigenetics, apoptosis, and others. Among these, immunomodulation stands out due to its close connection with cancer treatment. Finally, we discuss the limitations of the current research and propose new perspectives and directions for future studies.

Indexed as

Gastrointestinal MicrobiomeGastrointestinal NeoplasmsMouthDysbiosisHumansFusobacterium nucleatumGastrointestinal cancersOral microbesPorphyromonas gingivalis

Identifiers

PMID40186840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.